Gray matter correlates of childhood maltreatment in the context of major depression: searching for replicability in a multi-cohort brain-wide association study of 3225 adults DOI Creative Commons
Janik Goltermann, Nils R. Winter, Susanne Meinert

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 16, 2024

Childhood maltreatment effects on cerebral gray matter have been frequently discussed as a neurobiological pathway for depression. However, localizations are highly heterogeneous, and recent reports questioned the replicability of mental health neuroimaging findings. Here, we investigate correlates (measured retrospectively via Trauma Questionnaire) across three large adult cohorts (total N=3225). Pooling revealed maltreatment-related reductions, with most extensive when not controlling depression diagnosis (maximum partial R 2 =.022). none these significantly replicated cohorts. Non-replicability was consistent variety subtypes operationalizations, well subgroup analyses without depression, stratified by sex. In this work show that there is little evidence childhood maltreatment, adequately psychopathology. This underscores need to focus research in neuroimaging.

Language: Английский

Neural, cognitive and psychopathological signatures of a prosocial or delinquent peer environment during early adolescence DOI Creative Commons
Yu Liu,

Songjun Peng,

Xinran Wu

et al.

Developmental Cognitive Neuroscience, Journal Year: 2025, Volume and Issue: 73, P. 101566 - 101566

Published: May 9, 2025

Language: Английский

Citations

0
Power and reproducibility in the external validation of brain-phenotype predictions DOI
Matthew Rosenblatt, Link Tejavibulya, Huili Sun

et al.

Nature Human Behaviour, Journal Year: 2024, Volume and Issue: 8(10), P. 2018 - 2033

Published: July 31, 2024

Language: Английский

Citations

3
Power and reproducibility in the external validation of brain-phenotype predictions DOI Creative Commons
Matthew Rosenblatt, Link Tejavibulya, Chris C. Camp

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 30, 2023

Identifying reproducible and generalizable brain-phenotype associations is a central goal of neuroimaging. Consistent with this goal, prediction frameworks evaluate models in unseen data. Most studies train model the same dataset. However, external validation, or evaluation an dataset, provides better assessment robustness generalizability. Despite promise validation calls for its usage, statistical power such has yet to be investigated. In work, we ran over 60 million simulations across several datasets, phenotypes, sample sizes understand how training datasets affect power. We found that prior used prone low power, which may lead false negatives effect size inflation. Furthermore, increases led increased simulated directly following theoretical curves, whereas changes dataset offset curves. Finally, compared performance within performance. The within-dataset was typically

Language: Английский

Citations

3
Gray matter correlates of childhood maltreatment in the context of major depression: searching for replicability in a multi-cohort brain-wide association study of 3225 adults DOI Creative Commons
Janik Goltermann, Nils R. Winter, Susanne Meinert

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 16, 2024

Childhood maltreatment effects on cerebral gray matter have been frequently discussed as a neurobiological pathway for depression. However, localizations are highly heterogeneous, and recent reports questioned the replicability of mental health neuroimaging findings. Here, we investigate correlates (measured retrospectively via Trauma Questionnaire) across three large adult cohorts (total N=3225). Pooling revealed maltreatment-related reductions, with most extensive when not controlling depression diagnosis (maximum partial R 2 =.022). none these significantly replicated cohorts. Non-replicability was consistent variety subtypes operationalizations, well subgroup analyses without depression, stratified by sex. In this work show that there is little evidence childhood maltreatment, adequately psychopathology. This underscores need to focus research in neuroimaging.

Language: Английский

Citations

0