MULTIMODAL MISMATCH RESPONSES IN MOUSE AUDITORY CORTEX DOI Creative Commons
Magdalena Sołyga, Georg B. Keller

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 1, 2023

SUMMARY Our movements result in predictable sensory feedback that is often multimodal. Based on deviations between predictions and actual input, primary areas of cortex have been shown to compute sensorimotor prediction errors. How errors one modality influence the computation another still unclear. To investigate multimodal mouse auditory (ACx), we used a virtual environment experimentally couple running both self-generated visual feedback. Using two-photon microscopy, first characterized responses layer 2/3 (L2/3) neurons sounds, stimuli, onsets found all three stimuli. Probing evoked by audiomotor mismatches, they closely resemble visuomotor mismatch (V1). Finally, testing for cross modal coupling sound amplitude flow speed running, were amplified when paired with concurrent mismatches. results demonstrate non-hierarchical interactions shape error cortical L2/3.

Language: Английский

Brain-wide representations of prior information in mouse decision-making DOI Creative Commons

Charles Findling,

Félix Hubert,

Luigi Acerbi

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: July 4, 2023

The neural representations of prior information about the state world are poorly understood. To investigate them, we examined brain-wide Neuropixels recordings and widefield calcium imaging collected by International Brain Laboratory. Mice were trained to indicate location a visual grating stimulus, which appeared on left or right with probability alternating between 0.2 0.8 in blocks variable length. We found that mice estimate this thereby improve their decision accuracy. Furthermore, report subjective is encoded at least 20% 30% brain regions which, remarkably, span all levels processing, from early sensory areas (LGd, VISp) motor (MOs, MOp, GRN) high level cortical (ACAd, ORBvl). This widespread representation consistent model Bayesian inference involving loops areas, as opposed incorporated only decision-making areas. study offers first perspective encoding cellular resolution, underscoring importance using large scale single standardized task.

Language: Английский

Citations

39
Predictive neural computations in the cerebellum contribute to motor planning and faster behavioral responses in larval zebrafish DOI Creative Commons
Sriram Narayanan, Aalok Varma, Vatsala Thirumalai

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(1)

Published: Jan. 3, 2024

The ability to predict the future based on past experience lies at core of brain's adapt behavior. However, neural mechanisms that participate in generating and updating predictions are not clearly understood. Further, evolutionary antecedents prevalence predictive processing among vertebrates even less explored. Here, we show evidence via involvement cerebellar circuits larval zebrafish. We presented stereotyped optic flow stimuli zebrafish evoke swims discovered lesioning cerebellum abolished prediction-dependent modulation swim latency. When expectations direction did match with reality, error signals arrive Purkinje cells olivary climbing fibers, whereas granule encode expectation. Strong representations expectation correlate faster responses vice versa. In sum, our results for nonmammalian cerebellum, an evolutionarily conserved brain structure.

Language: Английский

Citations

11
Multimodal mismatch responses in mouse auditory cortex DOI Open Access
Magdalena Sołyga, Georg B. Keller

Published: Jan. 28, 2025

Our movements result in predictable sensory feedback that is often multimodal. Based on deviations between predictions and actual input, primary areas of cortex have been shown to compute sensorimotor prediction errors. How errors one modality influence the computation another still unclear. To investigate multimodal mouse auditory (ACx), we used a virtual environment experimentally couple running both self-generated visual feedback. Using two-photon microscopy, first characterized responses layer 2/3 (L2/3) neurons sounds, stimuli, onsets found all three stimuli. Probing evoked by audiomotor mismatches, they closely resemble visuomotor mismatch (V1). Finally, testing for cross modal coupling sound amplitude flow speed running, were amplified when paired with concurrent mismatches. results demonstrate non-hierarchical interactions shape error cortical L2/3.

Language: Английский

Citations

0
Multimodal mismatch responses in mouse auditory cortex DOI Creative Commons
Magdalena Sołyga, Georg B. Keller

eLife, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 10, 2025

Our movements result in predictable sensory feedback that is often multimodal. Based on deviations between predictions and actual input, primary areas of cortex have been shown to compute sensorimotor prediction errors. How errors one modality influence the computation another still unclear. To investigate multimodal mouse auditory cortex, we used a virtual environment experimentally couple running both self-generated visual feedback. Using two-photon microscopy, first characterized responses layer 2/3 (L2/3) neurons sounds, stimuli, onsets found all three stimuli. Probing evoked by audiomotor (AM) mismatches, they closely resemble visuomotor (VM) mismatch (V1). Finally, testing for cross modal AM coupling sound amplitude flow speed running, were amplified when paired with concurrent VM mismatches. results demonstrate non-hierarchical interactions shape error cortical L2/3.

Language: Английский

Citations

0
Multimodal mismatch responses in mouse auditory cortex DOI Open Access
Magdalena Sołyga, Georg B. Keller

Published: March 22, 2024

Our movements result in predictable sensory feedback that is often multimodal. Based on deviations between predictions and actual input, primary areas of cortex have been shown to compute sensorimotor prediction errors. How errors one modality influence the computation another still unclear. To investigate multimodal mouse auditory (ACx), we used a virtual environment experimentally couple running both self-generated visual feedback. Using two-photon microscopy, first characterized responses layer 2/3 (L2/3) neurons sounds, stimuli, onsets found all three stimuli. Probing evoked by audiomotor mismatches, they closely resemble visuomotor mismatch (V1). Finally, testing for cross modal coupling sound amplitude flow speed running, were amplified when paired with concurrent mismatches. results demonstrate non-hierarchical interactions shape error cortical L2/3.

Language: Английский

Citations

2
MULTIMODAL MISMATCH RESPONSES IN MOUSE AUDITORY CORTEX DOI Open Access
Magdalena Sołyga, Georg B. Keller

Published: Nov. 18, 2024

Our movements result in predictable sensory feedback that is often multimodal. Based on deviations between predictions and actual input, primary areas of cortex have been shown to compute sensorimotor prediction errors. How errors one modality influence the computation another still unclear. To investigate multimodal mouse auditory (ACx), we used a virtual environment experimentally couple running both self-generated visual feedback. Using two-photon microscopy, first characterized responses layer 2/3 (L2/3) neurons sounds, stimuli, onsets found all three stimuli. Probing evoked by audiomotor mismatches, they closely resemble visuomotor mismatch (V1). Finally, testing for cross modal coupling sound amplitude flow speed running, were amplified when paired with concurrent mismatches. results demonstrate non-hierarchical interactions shape error cortical L2/3. *** Dear reader, please note this manuscript formatted standard submission format, statistical information provided Table S1.

Language: Английский

Citations

2
MULTIMODAL MISMATCH RESPONSES IN MOUSE AUDITORY CORTEX DOI Open Access
Magdalena Sołyga, Georg B. Keller

Published: March 23, 2024

Our movements result in predictable sensory feedback that is often multimodal. Based on deviations between predictions and actual input, primary areas of cortex have been shown to compute sensorimotor prediction errors. How errors one modality influence the computation another still unclear. To investigate multimodal mouse auditory cortex, we used a virtual environment experimentally couple running both self-generated visual feedback. Using two-photon microscopy, first characterized responses layer 2/3 (L2/3) neurons sounds, stimuli, onsets found all three stimuli. Probing evoked by audiomotor (AM) mismatches, they closely resemble visuomotor (VM) mismatch (V1). Finally, testing for cross modal AM coupling sound amplitude flow speed running, were amplified when paired with concurrent VM mismatches. results demonstrate non-hierarchical interactions shape error cortical L2/3.

Language: Английский

Citations

1
MULTIMODAL MISMATCH RESPONSES IN MOUSE AUDITORY CORTEX DOI Creative Commons
Magdalena Sołyga, Georg B. Keller

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 1, 2023

SUMMARY Our movements result in predictable sensory feedback that is often multimodal. Based on deviations between predictions and actual input, primary areas of cortex have been shown to compute sensorimotor prediction errors. How errors one modality influence the computation another still unclear. To investigate multimodal mouse auditory (ACx), we used a virtual environment experimentally couple running both self-generated visual feedback. Using two-photon microscopy, first characterized responses layer 2/3 (L2/3) neurons sounds, stimuli, onsets found all three stimuli. Probing evoked by audiomotor mismatches, they closely resemble visuomotor mismatch (V1). Finally, testing for cross modal coupling sound amplitude flow speed running, were amplified when paired with concurrent mismatches. results demonstrate non-hierarchical interactions shape error cortical L2/3.

Language: Английский

Citations

0