Chronotropic Incompetence among People with HIV Improves with Exercise Training in the Exercise for Healthy Aging Study DOI Creative Commons
Matthew S. Durstenfeld, Melissa P. Wilson, Catherine M. Jankowski

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 11, 2023

Abstract Background People with HIV (PWH) have lower exercise capacity compared to uninfected peers, which may be explained by chronotropic incompetence (CI), the inability increase heart rate during exercise. Methods The Exercise for Healthy Aging Study included adults ages 50-75 and without HIV. Participants completed 12 weeks of moderate intensity exercise, before randomization or high additional weeks. We adjusted reserve (AHRR; CI <80%) on cardiopulmonary testing serostatus, change from baseline 24 using mixed effects models. Results Among 32 PWH 37 controls (median age 56, 7% female, mean BMI 28 kg/m 2 ), 28% 11% had at (p=0.067). AHRR was among (91 vs 102%; difference 11%, 95% 2.5-19.7; p=0.01). At week 12, normalized (+8%, 4-11; p<0.001) sustained (+5, 95%CI 1-9; p=0.008) no (95%CI –4 4; p=0.95; p interaction =0.004). After only 15% 10% (p=0.70). Conclusions Chronotropic contributes reduced improves training.

Language: Английский

Chronotropic Incompetence among People with HIV Improves with Exercise Training in the Exercise for Healthy Aging Study DOI Creative Commons
Matthew S. Durstenfeld, Melissa P. Wilson, Catherine M. Jankowski

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 11, 2023

Abstract Background People with HIV (PWH) have lower exercise capacity compared to uninfected peers, which may be explained by chronotropic incompetence (CI), the inability increase heart rate during exercise. Methods The Exercise for Healthy Aging Study included adults ages 50-75 and without HIV. Participants completed 12 weeks of moderate intensity exercise, before randomization or high additional weeks. We adjusted reserve (AHRR; CI <80%) on cardiopulmonary testing serostatus, change from baseline 24 using mixed effects models. Results Among 32 PWH 37 controls (median age 56, 7% female, mean BMI 28 kg/m 2 ), 28% 11% had at (p=0.067). AHRR was among (91 vs 102%; difference 11%, 95% 2.5-19.7; p=0.01). At week 12, normalized (+8%, 4-11; p<0.001) sustained (+5, 95%CI 1-9; p=0.008) no (95%CI –4 4; p=0.95; p interaction =0.004). After only 15% 10% (p=0.70). Conclusions Chronotropic contributes reduced improves training.

Language: Английский

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