Epigenetic regulation of global proteostasis dynamics by RBBP5 ensures mammalian organismal health DOI Creative Commons
Syeda Kubra, Michelle Sun, William Dion

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 13, 2024

Proteostasis is vital for cellular health, with disruptions leading to pathologies including aging, neurodegeneration and metabolic disorders. Traditionally, proteotoxic stress responses were studied as acute reactions various noxious factors; however, recent evidence reveals that many proteostasis stress-response genes exhibit ∼12-hour ultradian rhythms under physiological conditions in mammals. These rhythms, driven by an XBP1s-dependent 12h oscillator, are crucial managing proteostasis. By exploring the chromatin landscape of murine hepatic we identified RBBP5, a key subunit COMPASS complex writing H3K4me3, essential epigenetic regulator RBBP5 indispensable regulating both oscillator transcriptional response stress, acting co-activator transcription factor XBP1s. ablation leads increased sensitivity chronic inflammation, steatosis mice, along impaired autophagy reduced cell survival

Language: Английский

Preservation of ∼12-h ultradian rhythms of gene expression of mRNA and protein metabolism in the absence of canonical circadian clock DOI Creative Commons
Bokai Zhu, Silvia Liu

Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14

Published: May 30, 2023

Introduction: Besides the ∼24-h circadian rhythms, ∼12-h ultradian rhythms of gene expression, metabolism and behaviors exist in animals ranging from crustaceans to mammals. Three major hypotheses were proposed on origin mechanisms regulation namely, that they are not cell-autonomous controlled by a combination clock environmental cues, regulated two anti-phase transcription factors cell autonomous manner, or established oscillator. Methods: To distinguish among these possibilities, we performed post hoc analysis high temporal resolution transcriptome dataset cells lacking canonical clock. Results: In both liver BMAL1 knockout mice Drosophila S2 cells, observed robust prevalent expression enriched fundamental processes mRNA protein show large convergence with those identified wild-type liver. Bioinformatics further predicted ELF1 ATF6B as putative regulating independently fly mice. Discussion: These findings provide additional evidence support existence an evolutionarily conserved 12-h oscillator controls multiple species.

Language: Английский

Citations

13
Epigenetic regulation of global proteostasis dynamics by RBBP5 ensures mammalian organismal health DOI Creative Commons
Syeda Kubra, Michelle Sun, William Dion

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 13, 2024

Proteostasis is vital for cellular health, with disruptions leading to pathologies including aging, neurodegeneration and metabolic disorders. Traditionally, proteotoxic stress responses were studied as acute reactions various noxious factors; however, recent evidence reveals that many proteostasis stress-response genes exhibit ∼12-hour ultradian rhythms under physiological conditions in mammals. These rhythms, driven by an XBP1s-dependent 12h oscillator, are crucial managing proteostasis. By exploring the chromatin landscape of murine hepatic we identified RBBP5, a key subunit COMPASS complex writing H3K4me3, essential epigenetic regulator RBBP5 indispensable regulating both oscillator transcriptional response stress, acting co-activator transcription factor XBP1s. ablation leads increased sensitivity chronic inflammation, steatosis mice, along impaired autophagy reduced cell survival

Language: Английский

Citations

0