D-β-hydroxybutyrate stabilizes hippocampal CA3-CA1 circuit during acute insulin resistance DOI Creative Commons
Bartosz Kula, Botond Antal, Corey Weistuch

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 24, 2023

The brain primarily relies on glycolysis for mitochondrial respiration but switches to alternative fuels such as ketone bodies (KBs) when less glucose is available. Neuronal KB uptake, which does not rely transporter 4 (GLUT4) or insulin, has shown promising clinical applicability in alleviating the neurological and cognitive effects of disorders with hypometabolic components. However, specific mechanisms by interventions affect neuronal functions are poorly understood. In this study, we pharmacologically blocked GLUT4 investigate exogenous D-β-hydroxybutyrate (D-βHb) mouse metabolism during acute insulin resistance (AIR). We found that both AIR D-βHb had distinct impacts across compartments: decreased synaptic activity long-term potentiation (LTP) impaired axonal conduction, synchronization, action potential (AP) properties, while rescued associated LTP.

Language: Английский

D-β-hydroxybutyrate stabilizes hippocampal CA3-CA1 circuit during acute insulin resistance DOI Creative Commons
Bartosz Kula, Botond Antal, Corey Weistuch

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 24, 2023

The brain primarily relies on glycolysis for mitochondrial respiration but switches to alternative fuels such as ketone bodies (KBs) when less glucose is available. Neuronal KB uptake, which does not rely transporter 4 (GLUT4) or insulin, has shown promising clinical applicability in alleviating the neurological and cognitive effects of disorders with hypometabolic components. However, specific mechanisms by interventions affect neuronal functions are poorly understood. In this study, we pharmacologically blocked GLUT4 investigate exogenous D-β-hydroxybutyrate (D-βHb) mouse metabolism during acute insulin resistance (AIR). We found that both AIR D-βHb had distinct impacts across compartments: decreased synaptic activity long-term potentiation (LTP) impaired axonal conduction, synchronization, action potential (AP) properties, while rescued associated LTP.

Language: Английский

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