Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 163, P. 105749 - 105749

Published: June 3, 2024

The introduction of sex-as-a-biological-variable policies at funding agencies around the world has led to an explosion very recent observations sex differences in biology underlying pain. This review considers evidence sexually dimorphic mechanisms mediating pain hypersensitivity, derived from modern assays persistent rodent animal models. Three well-studied findings are described detail: male-specific role spinal cord microglia, female-specific calcitonin gene-related peptide (CGRP), and prolactin its receptor. Other sex-specific molecular involvement subjected pathway analyses reveal least one novel hypothesis: that females may preferentially use Th1 males Th2 T cell activity mediate chronic

Language: Английский