Associations between alcohol use disorder polygenic score and remission in participants from high‐risk families and the Indiana Biobank DOI Creative Commons
Dongbing Lai, Sally I‐Chun Kuo, Leah Wetherill

et al.

Alcohol Clinical and Experimental Research, Journal Year: 2023, Volume and Issue: 48(2), P. 283 - 294

Published: Dec. 6, 2023

Abstract Background In the United States, ~50% of individuals who meet criteria for alcohol use disorder (AUD) during their lifetimes do not remit. We previously reported that a polygenic score AUD (PGS ) was positively associated with severity as measured by DSM‐5 lifetime criterion count, and negatively remission. Thus, we hypothesized PGS would be Methods Individuals European (EA) African ancestry (AA) from Collaborative Study on Genetics Alcoholism (COGA) met AUD, two EA cohorts ascertained studies liver diseases substance disorders Indiana Biobank were included. COGA, 12‐month remission defined any period ≥12 consecutive months without meeting except craving further categorized abstinent non‐abstinent . Biobank, based ICD codes could distinguished or Sex age included covariates. COGA analyses additional adjustment severity, family history remission, treatment history. Results EA, ( p ≤ 0.013, β s between −0.15 −0.10) after adjusting all contrast to findings, = 0.004, 0.28) in cohort but 0.17, 0.15). Conclusions independent behavioral measures The discrepant results reflect different ascertainment strategies: participants older had higher rates disease, suggesting these remitted due alcohol‐related health conditions manifested later life.

Language: Английский

Alcohol milestones and internalizing, externalizing, and executive function: longitudinal and polygenic score associations DOI Creative Commons
Sarah E. Paul, David A. A. Baranger, Emma C. Johnson

et al.

Psychological Medicine, Journal Year: 2024, Volume and Issue: 54(10), P. 2644 - 2657

Published: May 9, 2024

Although the link between alcohol involvement and behavioral phenotypes (e.g. impulsivity, negative affect, executive function [EF]) is well-established, directionality of these associations, specificity to stages involvement, extent shared genetic liability remain unclear. We estimate longitudinal associations transitions among milestones, phenotypes, indices risk.

Language: Английский

Citations

0
Associations between alcohol use disorder polygenic score and remission in participants from high‐risk families and the Indiana Biobank DOI Creative Commons
Dongbing Lai, Sally I‐Chun Kuo, Leah Wetherill

et al.

Alcohol Clinical and Experimental Research, Journal Year: 2023, Volume and Issue: 48(2), P. 283 - 294

Published: Dec. 6, 2023

Abstract Background In the United States, ~50% of individuals who meet criteria for alcohol use disorder (AUD) during their lifetimes do not remit. We previously reported that a polygenic score AUD (PGS ) was positively associated with severity as measured by DSM‐5 lifetime criterion count, and negatively remission. Thus, we hypothesized PGS would be Methods Individuals European (EA) African ancestry (AA) from Collaborative Study on Genetics Alcoholism (COGA) met AUD, two EA cohorts ascertained studies liver diseases substance disorders Indiana Biobank were included. COGA, 12‐month remission defined any period ≥12 consecutive months without meeting except craving further categorized abstinent non‐abstinent . Biobank, based ICD codes could distinguished or Sex age included covariates. COGA analyses additional adjustment severity, family history remission, treatment history. Results EA, ( p ≤ 0.013, β s between −0.15 −0.10) after adjusting all contrast to findings, = 0.004, 0.28) in cohort but 0.17, 0.15). Conclusions independent behavioral measures The discrepant results reflect different ascertainment strategies: participants older had higher rates disease, suggesting these remitted due alcohol‐related health conditions manifested later life.

Language: Английский

Citations

1