Comparative analysis of amphibian genomes: An emerging resource for basic and applied research DOI Creative Commons
Tiffany A. Kosch, Andrew J. Crawford, Rachel Lockridge Mueller

et al.

Molecular Ecology Resources, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 4, 2024

Abstract Amphibians are the most threatened group of vertebrates and in dire need conservation intervention to ensure their continued survival. They exhibit unique features including a high diversity reproductive strategies, permeable specialized skin capable producing toxins antimicrobial compounds, multiple genetic mechanisms sex determination some lineages, ability regenerate limbs organs. Although genomic approaches would shed light on these traits aid conservation, sequencing assembly amphibian genomes has lagged behind other taxa due comparatively large genome sizes. Fortunately, development long‐read technologies initiatives led recent burst new assemblies. growing, field genomics suffers from lack annotation resources, tools for working with challenging high‐quality assemblies clades amphibians. Here, we analyse 51 publicly available evaluate usefulness functional research. We report considerable variation quality completeness highest transposable element repeat contents any vertebrate. Additionally, detected an association between content climatic variables. Our analysis provides evidence conserved synteny despite long divergence times this group, but also highlight inconsistencies chromosome naming orientation across discuss gaps phylogeny suggest key targets future endeavours. Finally, propose increased investment research promote conservation.

Language: Английский

Comparative analysis of amphibian genomes: An emerging resource for basic and applied research DOI Creative Commons
Tiffany A. Kosch, Andrew J. Crawford, Rachel Lockridge Mueller

et al.

Molecular Ecology Resources, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 4, 2024

Abstract Amphibians are the most threatened group of vertebrates and in dire need conservation intervention to ensure their continued survival. They exhibit unique features including a high diversity reproductive strategies, permeable specialized skin capable producing toxins antimicrobial compounds, multiple genetic mechanisms sex determination some lineages, ability regenerate limbs organs. Although genomic approaches would shed light on these traits aid conservation, sequencing assembly amphibian genomes has lagged behind other taxa due comparatively large genome sizes. Fortunately, development long‐read technologies initiatives led recent burst new assemblies. growing, field genomics suffers from lack annotation resources, tools for working with challenging high‐quality assemblies clades amphibians. Here, we analyse 51 publicly available evaluate usefulness functional research. We report considerable variation quality completeness highest transposable element repeat contents any vertebrate. Additionally, detected an association between content climatic variables. Our analysis provides evidence conserved synteny despite long divergence times this group, but also highlight inconsistencies chromosome naming orientation across discuss gaps phylogeny suggest key targets future endeavours. Finally, propose increased investment research promote conservation.

Language: Английский

Citations

6