Intergenerational transmission of polygenic predisposition for neuropsychiatric traits on emotional and behavioural difficulties in childhood DOI Open Access
Andrea G. Allegrini, Laurie J. Hannigan, Leonard Frach

et al.

Published: Nov. 21, 2023

Childhood emotional and behavioural difficulties frequently co-occur often precede diagnosed neuropsychiatric conditions. Delineating shared specific risk factors for early in life is therefore essential prevention strategies. Here, we focus on how a set of key parental shape their offspring’s symptoms. Leveraging data from 14,959 genotyped family trios the Norwegian Mother, Father Child Cohort Study (MoBa), model symptom level into general domains. We then investigate direct (genetically transmitted) indirect (environmentally mediated) contributions polygenic related traits to observe evidence consistent with an environmental route symptomatology beyond genetic transmission, while also demonstrating domain-specific contributions. Our findings pave way better identification pathways that can be targeted preventive interventions aiming interrupt intergenerational cycle transmission.

Language: Английский

Social-Science Genomics: Progress, Challenges, and Future Directions DOI
Daniel J. Benjamin, David Cesarini, Patrick Turley

et al.

SSRN Electronic Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Citations

0

Disentangling Genetic and Social Pathways of the Intergenerational Transmission of Cognitive Ability – A Nuclear Twin Family Study DOI Creative Commons
Tobias Wolfram, Mirko Ruks, Frank M. Spinath

et al.

Research in Social Stratification and Mobility, Journal Year: 2024, Volume and Issue: unknown, P. 100980 - 100980

Published: Sept. 1, 2024

Language: Английский

Citations

0

Genetic Nurture: Estimating the direct genetic effects of pediatric anthropometric traits DOI Creative Commons

Samuel Ghatan,

Jard de Vries, Jean‐Baptiste Pingault

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

Abstract Parental genetic variants can indirectly influence the traits of their child through environment, a concept termed "genetic nurture", or indirect effects (IGE). This study estimated direct (DGE), via allelic transmission, and IGE shaping height, body mass index (BMI), bone mineral density (BMD) in multi-ethnic Dutch pediatric cohort, examining children with repeated measurements at ages six, nine, thirteen. We imputed missing parental alleles from phased haplotypes 1,931,478 (MAF >1%), utilizing snipar (single nucleotide imputation parents). constructed polygenic risk scores (PRSs) jointly regressed proband’s trait on own PRS, while controlling for maternal paternal PRSs. A total 4,488 probands, data, underwent least one three specified measurements. found statistically significant DGE estimates across nine For instance, 71-77% BMI variance explained by BMI-PRS be attributed solely to DGE. reached significance only measured (Beta: 0.05, 95%CI: 0.01-0.09) thirteen 0.01-0.09). Maternal were similar magnitude all our analyses. Our findings indicate that nurture has limited anthropometric during formative years. In addition, we do not observe differences between contributions these traits, opposite stronger nurturing effect reported other traits.

Language: Английский

Citations

0

Intergenerational transmission of polygenic predisposition for neuropsychiatric traits on emotional and behavioural difficulties in childhood DOI Open Access
Andrea G. Allegrini, Laurie J. Hannigan, Leonard Frach

et al.

Published: Nov. 21, 2023

Childhood emotional and behavioural difficulties frequently co-occur often precede diagnosed neuropsychiatric conditions. Delineating shared specific risk factors for early in life is therefore essential prevention strategies. Here, we focus on how a set of key parental shape their offspring’s symptoms. Leveraging data from 14,959 genotyped family trios the Norwegian Mother, Father Child Cohort Study (MoBa), model symptom level into general domains. We then investigate direct (genetically transmitted) indirect (environmentally mediated) contributions polygenic related traits to observe evidence consistent with an environmental route symptomatology beyond genetic transmission, while also demonstrating domain-specific contributions. Our findings pave way better identification pathways that can be targeted preventive interventions aiming interrupt intergenerational cycle transmission.

Language: Английский

Citations

1