Childhood
emotional
and
behavioural
difficulties
frequently
co-occur
often
precede
diagnosed
neuropsychiatric
conditions.
Delineating
shared
specific
risk
factors
for
early
in
life
is
therefore
essential
prevention
strategies.
Here,
we
focus
on
how
a
set
of
key
parental
shape
their
offspring’s
symptoms.
Leveraging
data
from
14,959
genotyped
family
trios
the
Norwegian
Mother,
Father
Child
Cohort
Study
(MoBa),
model
symptom
level
into
general
domains.
We
then
investigate
direct
(genetically
transmitted)
indirect
(environmentally
mediated)
contributions
polygenic
related
traits
to
observe
evidence
consistent
with
an
environmental
route
symptomatology
beyond
genetic
transmission,
while
also
demonstrating
domain-specific
contributions.
Our
findings
pave
way
better
identification
pathways
that
can
be
targeted
preventive
interventions
aiming
interrupt
intergenerational
cycle
transmission.
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 11, 2024
Abstract
Parental
genetic
variants
can
indirectly
influence
the
traits
of
their
child
through
environment,
a
concept
termed
"genetic
nurture",
or
indirect
effects
(IGE).
This
study
estimated
direct
(DGE),
via
allelic
transmission,
and
IGE
shaping
height,
body
mass
index
(BMI),
bone
mineral
density
(BMD)
in
multi-ethnic
Dutch
pediatric
cohort,
examining
children
with
repeated
measurements
at
ages
six,
nine,
thirteen.
We
imputed
missing
parental
alleles
from
phased
haplotypes
1,931,478
(MAF
>1%),
utilizing
snipar
(single
nucleotide
imputation
parents).
constructed
polygenic
risk
scores
(PRSs)
jointly
regressed
proband’s
trait
on
own
PRS,
while
controlling
for
maternal
paternal
PRSs.
A
total
4,488
probands,
data,
underwent
least
one
three
specified
measurements.
found
statistically
significant
DGE
estimates
across
nine
For
instance,
71-77%
BMI
variance
explained
by
BMI-PRS
be
attributed
solely
to
DGE.
reached
significance
only
measured
(Beta:
0.05,
95%CI:
0.01-0.09)
thirteen
0.01-0.09).
Maternal
were
similar
magnitude
all
our
analyses.
Our
findings
indicate
that
nurture
has
limited
anthropometric
during
formative
years.
In
addition,
we
do
not
observe
differences
between
contributions
these
traits,
opposite
stronger
nurturing
effect
reported
other
traits.
Childhood
emotional
and
behavioural
difficulties
frequently
co-occur
often
precede
diagnosed
neuropsychiatric
conditions.
Delineating
shared
specific
risk
factors
for
early
in
life
is
therefore
essential
prevention
strategies.
Here,
we
focus
on
how
a
set
of
key
parental
shape
their
offspring’s
symptoms.
Leveraging
data
from
14,959
genotyped
family
trios
the
Norwegian
Mother,
Father
Child
Cohort
Study
(MoBa),
model
symptom
level
into
general
domains.
We
then
investigate
direct
(genetically
transmitted)
indirect
(environmentally
mediated)
contributions
polygenic
related
traits
to
observe
evidence
consistent
with
an
environmental
route
symptomatology
beyond
genetic
transmission,
while
also
demonstrating
domain-specific
contributions.
Our
findings
pave
way
better
identification
pathways
that
can
be
targeted
preventive
interventions
aiming
interrupt
intergenerational
cycle
transmission.
