Maternal choline supplementation lessens the behavioral dysfunction produced by developmental manganese exposure in a rodent model of ADHD DOI Open Access
Shanna L. Howard,

Stéphane A. Beaudin,

Barbara J. Strupp

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: June 26, 2023

Abstract Studies in children have reported associations between elevated manganese (Mn) exposure and ADHD-related symptoms of inattention, impulsivity/hyperactivity, psychomotor impairment. Maternal choline supplementation (MCS) during pregnancy/lactation may hold promise as a protective strategy because it has been shown to lessen cognitive dysfunction caused by numerous early insults. Our objectives were determine whether (1) developmental Mn alters behavioral reactivity/emotion regulation, addition impairing learning, attention, impulse control, sensorimotor function, (2) MCS protects against these Mn-induced impairments. Pregnant Long-Evans rats given standard diet, or diet supplemented with additional throughout gestation lactation (G3 - PND 21). Male offspring exposed orally 0 50 mg Mn/kg/day over 1–21. In adulthood, animals tested series tasks. lasting reactivity errors reward omission, recapitulating the constellation seen ADHD children. lessened attentional partially normalized committing an error not receiving expected but provided no protection learning dysfunction. absence exposure, produces benefits errors. To conclude, deficits consistent symptomology, offered some adverse effects, adding evidence that maternal is neuroprotective for improves functioning. Highlights Developmental causes symptomology. attention reactivity. control These data support efforts increase intake pregnancy, particularly individuals at risk neurotoxicant exposure.

Language: Английский

Neurotoxic effects of heavy metal pollutants in the environment: Focusing on epigenetic mechanisms DOI
Guangxia Yu,

Lingyan Wu,

Qianqian Su

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 345, P. 123563 - 123563

Published: Feb. 13, 2024

Language: Английский

Citations

27
Manganese in autism spectrum disorder and attention deficit hyperactivity disorder: The state of the art DOI Creative Commons
Michael Aschner, Airton C. Martins, Gustavo H. Oliveira‐Paula

et al.

Current Research in Toxicology, Journal Year: 2024, Volume and Issue: 6, P. 100170 - 100170

Published: Jan. 1, 2024

The objective of the present narrative review was to synthesize existing clinical and epidemiological findings linking manganese (Mn) exposure biomarkers autism spectrum disorder (ASD) attention deficit hyperactivity (ADHD), discuss key pathophysiological mechanisms neurodevelopmental disorders that may be affected by this metal. Existing data demonstrated both direct inverse association between Mn body burden ASD, or lack any relationship. In contrast, majority studies revealed significantly higher levels in subjects with ADHD, as well relationship inattention scores children, although several reported contradictory results. laboratory impaired animals following associated dopaminergic dysfunction neuroinflammation. Despite evidence on Mn-induced neurobiological alterations patients ASD a plethora neurotoxic effects overexposure interfere pathogenesis inherent these disorders. Specifically, overload shown impair not only neurotransmission, but also affect metabolism glutamine/glutamate, GABA, serotonin, noradrenaline, thus affecting neuronal signaling. turn, its ability induce oxidative stress, apoptosis, neuroinflammation, and/or neurogenesis. Nonetheless, additional detailed are required evaluate environmental at wide range concentrations estimate potential dose-dependent effects, genetic factors association.

Language: Английский

Citations

9
The dopamine hypothesis for ADHD: An evaluation of evidence accumulated from human studies and animal models DOI Creative Commons
Hayley J. MacDonald, Rune Kleppe, Peter D. Szigetvari

et al.

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 15, 2024

Multiple lines of evidence indicate that altered dopamine signaling may be involved in neuropsychiatric disorders and common behavioral traits. Here we critically review collected during the past 40-plus years supporting role dysfunction attention deficit hyperactivity disorder (ADHD). We recapitulate basic components dopaminergic central nervous system, focusing on core enzymes, transporters receptors monoaminergic functions, particularly striatal cortical regions. summarize key human brain imaging genetic studies reporting associations between neurotransmission traits, with an emphasis ADHD. also consider ADHD context animal models single gene, metabolic, neurological established system. Examining this way leads us to conclude there is for involvement but limited a hypo-dopaminergic state per se as component propose path forward increase our understanding traits should focus its clinical subgroups, development how it interacts other neurotransmitter systems.

Language: Английский

Citations

9
Maternal choline supplementation lessens the behavioral dysfunction produced by developmental manganese exposure in a rodent model of ADHD DOI
Shanna L. Howard,

Stéphane A. Beaudin,

Barbara J. Strupp

et al.

Neurotoxicology and Teratology, Journal Year: 2024, Volume and Issue: 102, P. 107337 - 107337

Published: Feb. 27, 2024

Language: Английский

Citations

4
Signal Transduction Associated with Mn-induced Neurological Dysfunction DOI

Xiao-wei Zheng,

Yuanyuan Fang, Junjie Lin

et al.

Biological Trace Element Research, Journal Year: 2023, Volume and Issue: 202(9), P. 4158 - 4169

Published: Dec. 29, 2023

Language: Английский

Citations

3
Sensorimotor dysfunction due to developmental manganese exposure is less severe in adult female than male rats and partially improved by acute methylphenidate treatment DOI

Stéphane A. Beaudin,

Samantha Gorman,

Naomi Schilpp

et al.

Neurotoxicology and Teratology, Journal Year: 2024, Volume and Issue: 102, P. 107330 - 107330

Published: Feb. 1, 2024

Language: Английский

Citations

0
Neurotoxicology of Metals DOI

Freeman Lewis,

Somaiyeh Azmoun,

Daniel Shoieb

et al.

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Citations

0
Maternal choline supplementation lessens the behavioral dysfunction produced by developmental manganese exposure in a rodent model of ADHD DOI Open Access
Shanna L. Howard,

Stéphane A. Beaudin,

Barbara J. Strupp

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: June 26, 2023

Abstract Studies in children have reported associations between elevated manganese (Mn) exposure and ADHD-related symptoms of inattention, impulsivity/hyperactivity, psychomotor impairment. Maternal choline supplementation (MCS) during pregnancy/lactation may hold promise as a protective strategy because it has been shown to lessen cognitive dysfunction caused by numerous early insults. Our objectives were determine whether (1) developmental Mn alters behavioral reactivity/emotion regulation, addition impairing learning, attention, impulse control, sensorimotor function, (2) MCS protects against these Mn-induced impairments. Pregnant Long-Evans rats given standard diet, or diet supplemented with additional throughout gestation lactation (G3 - PND 21). Male offspring exposed orally 0 50 mg Mn/kg/day over 1–21. In adulthood, animals tested series tasks. lasting reactivity errors reward omission, recapitulating the constellation seen ADHD children. lessened attentional partially normalized committing an error not receiving expected but provided no protection learning dysfunction. absence exposure, produces benefits errors. To conclude, deficits consistent symptomology, offered some adverse effects, adding evidence that maternal is neuroprotective for improves functioning. Highlights Developmental causes symptomology. attention reactivity. control These data support efforts increase intake pregnancy, particularly individuals at risk neurotoxicant exposure.

Language: Английский

Citations

0