Motor Control of Distinct Layer 6 Corticothalamic Feedback Circuits DOI Creative Commons
Luis E. Martinetti,

Dawn M. Autio,

Shane R. Crandall

et al.

eNeuro, Journal Year: 2024, Volume and Issue: 11(7), P. ENEURO.0255 - 24.2024

Published: June 26, 2024

Layer 6 corticothalamic (L6 CT) neurons provide massive input to the thalamus, and these feedback connections enable cortex influence its own sensory by modulating thalamic excitability. However, functional role(s) serves during processing is unclear. One hypothesis that CT under control of extrasensory signals originating from higher-order cortical areas, yet we know nothing about mechanisms such control. It also unclear whether regulation specific with distinct connectivity. Using mice (either sex) combined in vitro electrophysiology techniques, optogenetics, retrograde labeling, describe studies vibrissal primary motor (vM1) influences on different somatosensory (vS1) intrathalamic axonal projections. We found vM1 inputs are highly selective, evoking stronger postsynaptic responses projecting dual ventral posterior medial nucleus (VPm) (POm) located lower L6a than VPm-only–projecting cells upper L6a. A targeted analysis synapses involved revealed greater responsiveness Dual was due their distinctive intrinsic membrane properties synaptic mechanisms. These data demonstrate vS1 has at least two discrete L6 subcircuits distinguished projection patterns, physiology, connectivity vM1. Our results insights into how a subcircuit may serve specialized roles contextual modulation tactile-related thalamus active vibrissa movements.

Language: Английский

Motor Control of Distinct Layer 6 Corticothalamic Feedback Circuits DOI Creative Commons
Luis E. Martinetti,

Dawn M. Autio,

Shane R. Crandall

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 23, 2024

ABSTRACT Layer 6 corticothalamic (L6 CT) neurons provide massive input to the thalamus, and these feedback connections enable cortex influence its own sensory by modulating thalamic excitability. However, functional role(s) serves during processing is unclear. One hypothesis that CT under control of extra-sensory signals originating from higher-order cortical areas, yet we know nothing about mechanisms such control. It also unclear whether regulation specific with distinct connectivity. Using mice (either sex) combined in vitro electrophysiology techniques, optogenetics, retrograde labeling, describe studies vibrissal primary motor (vM1) influences on different somatosensory (vS1) intrathalamic axonal projections. We found vM1 inputs are highly selective, evoking stronger postsynaptic responses Dual ventral posterior medial nucleus (VPm) (POm) projecting located lower L6a than VPm-only cells upper L6a. A targeted analysis synapses involved revealed greater responsiveness was due their distinctive intrinsic membrane properties synaptic mechanisms. These data demonstrate vS1 has at least two discrete L6 subcircuits distinguished projection patterns, physiology, connectivity vM1. Our results insights into how a subcircuit may serve specialized roles contextual modulation tactile-related thalamus active vibrissa movements. SIGNIFICANCE STATEMENT circuits ubiquitous across mammalian species modalities, activities have strong excitability information throughput neocortex. Despite clear evidence effects relatively little themselves regulated. show strongly excites subclass innervate both core nuclei rather those exclusively targeting thalamus. The cortico-cortico-thalamic pathway formed establishes circuit-level substrate for supporting operating guidance ongoing activities.

Language: Английский

Citations

2
Multiple distinct timescales of rapid sensory adapation in the thalamocortical circuit DOI Creative Commons
Yi Juin Liew, Elaida Dimwamwa, Nathaniel C. Wright

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 6, 2024

Numerous studies have shown that neuronal representations in sensory pathways are far from static but instead strongly shaped by the complex properties of inputs they receive. Adaptation dynamically shapes neural signaling underlies our perception world yet remains poorly understood. We investigated rapid adaptation across timescales hundreds milliseconds to seconds through simultaneous multi-electrode recordings ventro-posteromedial nucleus thalamus (VPm) and layer 4 primary somatosensory cortex (S1) male female anesthetized mice response controlled, persistent whisker stimulation. Observations VPm S1 reveal a degree progresses pathway. Signatures two distinct firing rates both thalamic cortical populations were revealed, also reflected synchrony population thalamocortical synaptic efficacy was measured putatively monosynaptically connected pairs. Controlled optogenetic activation further demonstrated longer timescale observed is likely inherited slow decreases rate synchrony. Despite degraded responses, resulted shift coding strategy favors theoretical discrimination over detection adaptation. Overall, although multiple mechanisms contribute at timescales, support unifying framework on role processing.

Language: Английский

Citations

1
Motor Control of Distinct Layer 6 Corticothalamic Feedback Circuits DOI Creative Commons
Luis E. Martinetti,

Dawn M. Autio,

Shane R. Crandall

et al.

eNeuro, Journal Year: 2024, Volume and Issue: 11(7), P. ENEURO.0255 - 24.2024

Published: June 26, 2024

Layer 6 corticothalamic (L6 CT) neurons provide massive input to the thalamus, and these feedback connections enable cortex influence its own sensory by modulating thalamic excitability. However, functional role(s) serves during processing is unclear. One hypothesis that CT under control of extrasensory signals originating from higher-order cortical areas, yet we know nothing about mechanisms such control. It also unclear whether regulation specific with distinct connectivity. Using mice (either sex) combined in vitro electrophysiology techniques, optogenetics, retrograde labeling, describe studies vibrissal primary motor (vM1) influences on different somatosensory (vS1) intrathalamic axonal projections. We found vM1 inputs are highly selective, evoking stronger postsynaptic responses projecting dual ventral posterior medial nucleus (VPm) (POm) located lower L6a than VPm-only–projecting cells upper L6a. A targeted analysis synapses involved revealed greater responsiveness Dual was due their distinctive intrinsic membrane properties synaptic mechanisms. These data demonstrate vS1 has at least two discrete L6 subcircuits distinguished projection patterns, physiology, connectivity vM1. Our results insights into how a subcircuit may serve specialized roles contextual modulation tactile-related thalamus active vibrissa movements.

Language: Английский

Citations

0