Patients Recovering from COVID-19 who Presented Anosmia During their Acute Episode have Behavioral, Functional, and Structural Brain Alterations DOI Creative Commons
Leonie Kausel, Alejandra Figueroa-Vargas, Francisco Zamorano

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 3, 2024

Abstract Patients recovering from COVID-19 commonly exhibit cognitive and brain alterations, yet the specific neuropathological mechanisms risk factors that underlie these alterations remain elusive. Given significant global incidence of COVID-19, identifying can distinguish individuals at developing medium or long-term is crucial for prioritizing follow-up care. Here, we report findings a sample 100 patients who were affected by respiratory infection during pandemic. This comprised 73 adults with mild to moderate SARS-CoV-2 (who did not require invasive ventilatory assistance) 27 infections attributed other agents no history COVID-19. The participants underwent screening, decision-making task measure flexibility, magnetic resonance imaging evaluations. We assessed two clinical infection: presence anosmia requirement hospitalization due symptoms. Groups differ in age performance, but differentially performance. presented acute episode exhibited more impulsive changes alternatives after shift probabilities task, while required showed perseverative choices. Interestingly, correlated several measures, including decreases functional activity thinning cortical thickness parietal regions, loss white matter integrity corticospinal tracts parietal-thalamic fasciculi, among others. These results suggest could be factor may serve identify at-risk populations follow-up.

Language: Английский

Patients recovering from COVID-19 who presented with anosmia during their acute episode have behavioral, functional, and structural brain alterations DOI Creative Commons
Leonie Kausel, Alejandra Figueroa-Vargas, Francisco Zamorano

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Aug. 17, 2024

Patients recovering from COVID-19 commonly exhibit cognitive and brain alterations, yet the specific neuropathological mechanisms risk factors underlying these alterations remain elusive. Given significant global incidence of COVID-19, identifying that can distinguish individuals at developing is crucial for prioritizing follow-up care. Here, we report findings a sample patients consisting 73 adults with mild to moderate SARS-CoV-2 infection without signs respiratory failure 27 infections attributed other agents no history COVID-19. The participants underwent screening, decision-making task, MRI evaluations. We assessed presence anosmia requirement hospitalization. Groups did not differ in age or performance. who presented exhibited more impulsive alternative changes after shift probabilities (r = − 0.26, p 0.001), while required hospitalization showed perseverative choices 0.25, 0.003). Anosmia correlated measures, including decreased functional activity during thinning cortical thickness parietal regions, loss white matter integrity. Hence, could be factor considered when at-risk populations follow-up.

Language: Английский

Citations

6
Patients Recovering from COVID-19 who Presented Anosmia During their Acute Episode have Behavioral, Functional, and Structural Brain Alterations DOI Creative Commons
Leonie Kausel, Alejandra Figueroa-Vargas, Francisco Zamorano

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 3, 2024

Abstract Patients recovering from COVID-19 commonly exhibit cognitive and brain alterations, yet the specific neuropathological mechanisms risk factors that underlie these alterations remain elusive. Given significant global incidence of COVID-19, identifying can distinguish individuals at developing medium or long-term is crucial for prioritizing follow-up care. Here, we report findings a sample 100 patients who were affected by respiratory infection during pandemic. This comprised 73 adults with mild to moderate SARS-CoV-2 (who did not require invasive ventilatory assistance) 27 infections attributed other agents no history COVID-19. The participants underwent screening, decision-making task measure flexibility, magnetic resonance imaging evaluations. We assessed two clinical infection: presence anosmia requirement hospitalization due symptoms. Groups differ in age performance, but differentially performance. presented acute episode exhibited more impulsive changes alternatives after shift probabilities task, while required showed perseverative choices. Interestingly, correlated several measures, including decreases functional activity thinning cortical thickness parietal regions, loss white matter integrity corticospinal tracts parietal-thalamic fasciculi, among others. These results suggest could be factor may serve identify at-risk populations follow-up.

Language: Английский

Citations

0