Caenorhabditis Elegans as a Model for Environmental Epigenetics

Current Environmental Health Reports, Journal Year: 2025, Volume and Issue: 12(1)

Published: Jan. 20, 2025

Abstract Purpose of Review The burgeoning field environmental epigenetics has revealed the malleability epigenome and uncovered numerous instances its sensitivity to influences; however, pinpointing specific mechanisms that tie together triggers, epigenetic pathways, organismal responses proven difficult. This article describes how Caenorhabditis elegans can fill this gap, serving as a useful model for discovery molecular are conserved in humans. Recent Findings results show stressors such methylmercury, arsenite, starvation, heat, bacterial infection, mitochondrial inhibitors all have profound effects on epigenome, with some insults showing multiple generations. In cases, pathways connecting stressor been elucidated. For example, small RNA from pathogen Pseudomonas aeruginosa induces transgenerational learned avoidance by activating interference PIWI-interacting across generations downregulate, via Cer1 retrotransposon particles histone methylation, maco-1, gene functions sensory neurons regulate chemotaxis. Mitochondrial seem effect both DNA methylation mark 6mA may act within (mtDNA) stress response genes. Transgenerational transcriptional alcohol also worked out at single-nucleus resolution C. , demonstrating utility when combined modern sequencing technologies. Summary These recent studies highlight serve bridge between biochemical vitro experiments more associative findings epidemiological humans unveil possible influence epigenome. nematode is particularly well-suited thanks rapid generation time ability self-fertilize. connections various mechanisms, so take advantage advancements technologies, including single-cell techniques, gain unprecedented whole development will be critical.

Language: Английский

P. aeruginosacontrols bothC. elegansattraction and pathogenesis by regulating nitrogen assimilation

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 30, 2023

Detecting chemical signals is important for identifying food sources and avoiding harmful agents. Like most animals,

Language: Английский