Temporal dynamics of BMP/Nodal ratio drive tissue-specific gastrulation morphogenesis DOI Creative Commons
Alyssa Alaniz Emig, Megan A Hansen, Sandra L. Grimm

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 7, 2024

ABSTRACT Anteroposterior (AP) elongation of the vertebrate body plan is driven by convergence and extension (C&E) gastrulation movements in both mesoderm neuroectoderm, but how or whether molecular regulation C&E differs between tissues remains an open question. Using a zebrafish explant model AP axis extension, we show that neuroectoderm can be uncoupled ex vivo , morphogenesis individual results from distinct morphogen signaling dynamics. precise temporal manipulation BMP Nodal signaling, identify critical developmental window during which high low BMP/Nodal ratios induce neuroectoderm- mesoderm-driven C&E, respectively. Increased activity similarly enhances specifically ectoderm intact gastrulae, highlighting relevance our findings. Together, these demonstrate dynamics activate morphogenetic programs governing within tissues. SUMMARY STATEMENT embryo models, distinguish tissue-specific formation.

Language: Английский

Temporal dynamics of BMP/Nodal ratio drive tissue-specific gastrulation morphogenesis DOI Creative Commons
Alyssa Alaniz Emig, Megan A Hansen, Sandra L. Grimm

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 7, 2024

ABSTRACT Anteroposterior (AP) elongation of the vertebrate body plan is driven by convergence and extension (C&E) gastrulation movements in both mesoderm neuroectoderm, but how or whether molecular regulation C&E differs between tissues remains an open question. Using a zebrafish explant model AP axis extension, we show that neuroectoderm can be uncoupled ex vivo , morphogenesis individual results from distinct morphogen signaling dynamics. precise temporal manipulation BMP Nodal signaling, identify critical developmental window during which high low BMP/Nodal ratios induce neuroectoderm- mesoderm-driven C&E, respectively. Increased activity similarly enhances specifically ectoderm intact gastrulae, highlighting relevance our findings. Together, these demonstrate dynamics activate morphogenetic programs governing within tissues. SUMMARY STATEMENT embryo models, distinguish tissue-specific formation.

Language: Английский

Citations

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