Persistence of viral RNA in North American elk experimentally infected with an ancestral strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) DOI Creative Commons
Paola M. Boggiatto, Alexandra Buckley, Eric D. Cassmann

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: March 15, 2024

Abstract White-tailed deer (Odocoileus virginianus) have emerged as a potential reservoir host for SARS-CoV-2 given their susceptibility to infection and demonstrated high rates of seroprevalence across the United States. As circulates within free-ranging white-tailed populations, there is risk transmission other wildlife species even back human population. The goal this study was determine susceptibility, shedding, immune response North American elk (Cervus elaphus canadensis) experimental with SARS-CoV-2, if another wide-ranging cervid could potentially serve virus. Here we demonstrate that while do not develop clinical signs disease, they neutralizing antibody infection, suggesting virus capable replicating in mammalian host. Additionally, RNA presence medial retropharyngeal lymph nodes infected three weeks after infection. Consistent previous observations humans, these data may highlight mechanism viral persistence elk.

Language: Английский

Persistence of viral RNA in North American elk experimentally infected with an ancestral strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) DOI Creative Commons
Paola M. Boggiatto, Alexandra Buckley, Eric D. Cassmann

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: March 15, 2024

Abstract White-tailed deer (Odocoileus virginianus) have emerged as a potential reservoir host for SARS-CoV-2 given their susceptibility to infection and demonstrated high rates of seroprevalence across the United States. As circulates within free-ranging white-tailed populations, there is risk transmission other wildlife species even back human population. The goal this study was determine susceptibility, shedding, immune response North American elk (Cervus elaphus canadensis) experimental with SARS-CoV-2, if another wide-ranging cervid could potentially serve virus. Here we demonstrate that while do not develop clinical signs disease, they neutralizing antibody infection, suggesting virus capable replicating in mammalian host. Additionally, RNA presence medial retropharyngeal lymph nodes infected three weeks after infection. Consistent previous observations humans, these data may highlight mechanism viral persistence elk.

Language: Английский

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