Transcriptomic Signatures of Zika Virus Infection in Patients and a Cell Culture Model DOI Creative Commons

Gillian Berglund,

Claudia D. Lennon, Pheonah Badu

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(7), P. 1499 - 1499

Published: July 22, 2024

Zika virus (ZIKV), a re-emerging flavivirus, is associated with devasting developmental and neurological disease outcomes particularly in infants infected utero. Towards understanding the molecular underpinnings of unique ZIKV pathologies, numerous transcriptome-wide studies have been undertaken. Notably, these overlooked assimilation RNA-seq analysis from ZIKV-infected patients cell culture model systems. In this study we find that ZIKV-infection human lung adenocarcinoma A549 cells, mirrored both transcriptional alternative splicing profiles previously published data peripheral blood mononuclear cells collected pediatric during early acute, late convalescent phases infection. Our analyses show infection cultured correlates changes patients, while overlap was not as extensive. Overall, our indicate systems support dissection select detected establishes groundwork for future elucidating biological implications

Language: Английский

The Dual Roles of Activating Transcription Factor 3 (ATF3) in Inflammation, Apoptosis, Ferroptosis, and Pathogen Infection Responses DOI Open Access
Shuang Liu,

Zhangcheng Li,

Shimei Lan

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 824 - 824

Published: Jan. 9, 2024

Transcription factors are pivotal regulators in the cellular life process. Activating transcription factor 3 (ATF3), a member of ATF/CREB (cAMP response element-binding protein) family, plays crucial role as cells respond to various stresses and damage. As factor, ATF3 significantly influences signal transduction regulation, orchestrating variety signaling pathways, including apoptosis, ferroptosis, differentiation. In addition, serves an essential link between inflammation, oxidative stress, immune responses. This review summarizes recent advances research on activation its regulating inflammatory responses, cell ferroptosis while exploring dual functions these processes. Additionally, this article discusses diseases related pathogenic microbial infections. Our may be helpful better understand responses disease progression, thus promoting advancements clinical treatments for inflammation stress-related diseases.

Language: Английский

Citations

41
Structure and dynamics of enterovirus genotype networks DOI Creative Commons
Nathânia Dábilla, Patrick Dolan

Science Advances, Journal Year: 2024, Volume and Issue: 10(25)

Published: June 19, 2024

Like all biological populations, viral populations exist as networks of genotypes connected through mutation. Mapping the topology these and quantifying population dynamics across them is crucial to understanding how adapt changes in their selective environment. The influence mutational especially profound that rapidly explore neighborhoods via high mutation rates. Using a single-cell sequencing method, scRNA-seq-enabled acquisition mRNA consensus haplotypes linking individual host transcriptomes (SEARCHLIGHT), we captured assembled from hundreds infected cells, revealing complexity structures. We obtained parallel with cell transcriptome information, enabling us link transcriptional phenotypes genetic structures underlying virus adaptation. Our examination reveals common evolutionary enterovirus illustrates reach "tunnels" span landscapes maintain connection multiple adaptive simultaneously.

Language: Английский

Citations

4
ATF4 Signaling in HIV-1 Infection: Viral Subversion of a Stress Response Transcription Factor DOI Creative Commons

Adrien Corne,

Florine Adolphe, Jérôme Estaquier

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(3), P. 146 - 146

Published: Feb. 26, 2024

Cellular integrated stress response (ISR), the mitochondrial unfolded protein (UPRmt), and IFN signaling are associated with viral infections. Activating transcription factor 4 (ATF4) plays a pivotal role in these pathways controls expression of many genes involved redox processes, amino acid metabolism, misfolding, autophagy, apoptosis. The precise ATF4 during infection is unclear depends on cell hosts, agents, models. Furthermore, can be hijacked by pathogens to favor replication. In this review, we summarize ATF4-mediated infections, focusing human immunodeficiency virus 1 (HIV-1). We examine consequences activation for HIV-1 replication reactivation. autophagy apoptosis explored as context programmed deaths contribute depletion CD4 T cells. also participate establishment innate adaptive immunity that essential host control finally discuss putative paralogue, named ATF5, infection. This review underlines at crossroads multiple processes reflecting host–pathogen interactions.

Language: Английский

Citations

3
Zika virus infection in a cell culture model reflects the transcriptomic signatures in patients. DOI Creative Commons

Gillian Berglund,

Claudia D. Lennon,

Pheonah Badu

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 25, 2024

Zika virus (ZIKV), a re-emerging flavivirus, is associated with devasting developmental and neurological disease outcomes particularly in infants infected

Language: Английский

Citations

2
Transcriptomic Signatures of Zika Virus Infection in Patients and a Cell Culture Model DOI Creative Commons

Gillian Berglund,

Claudia D. Lennon, Pheonah Badu

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(7), P. 1499 - 1499

Published: July 22, 2024

Zika virus (ZIKV), a re-emerging flavivirus, is associated with devasting developmental and neurological disease outcomes particularly in infants infected utero. Towards understanding the molecular underpinnings of unique ZIKV pathologies, numerous transcriptome-wide studies have been undertaken. Notably, these overlooked assimilation RNA-seq analysis from ZIKV-infected patients cell culture model systems. In this study we find that ZIKV-infection human lung adenocarcinoma A549 cells, mirrored both transcriptional alternative splicing profiles previously published data peripheral blood mononuclear cells collected pediatric during early acute, late convalescent phases infection. Our analyses show infection cultured correlates changes patients, while overlap was not as extensive. Overall, our indicate systems support dissection select detected establishes groundwork for future elucidating biological implications

Language: Английский

Citations

2