The Rapidly Changing Patterns in Bacterial Co-Infections Reveal Peaks in Limited Gram Negatives during COVID-19 and Their Sharp Drop Post-Vaccination, Implying Potential Evolution of Co-Protection during Vaccine–Virus–Bacterial Interplay DOI Creative Commons
Kamaleldin B. Said, Ahmed Alsolami, Khalid Farhan Alshammari

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(2), P. 227 - 227

Published: Jan. 31, 2024

SARS-CoV-2 has caused the most devastating pandemic of all time in recent human history. However, there is a serious paucity high-quality data on aggravating factors and mechanisms co-infection. This study aimed to identify trending patterns bacterial co-infections types associated outcomes three phases pandemic. Using quality hospital data, we have investigated fatality rates, profiles, before, during, after COVID-19 vaccination. Out 389 isolates used different aspects, 298 were examined before during (n = 149 n during). In this group, death rates 32% compared only 7.4% with significant association (p-value 0.000000075). rate was 34% co-infected 170) non-co-infected patients 128), indicating highly value 0.00000000000088). analysis without other respiratory problems 28) indicated that among remaining 270 patients, occurred 30% 150) 0.8% 120) high p-value 0.00000000076. The vaccination showed decline Staphylococcus aureus concomitant peaks Gram negatives before/n including Klebsiella pneumonian 11/49 before/during, E. coli 10/24, A. baumannii 8/25, Ps. aeruginosa 5/16, S. 13/1. Nevertheless, post-vaccination phase 91), gender-specific for potential differences susceptibility. Methicillin-resistant dominated both genders followed by males females, latter gender showing higher isolations species. pneumoniae declined third place male patients. drastic K. strongly implied co-protection vaccines. Future would gain more insights into molecular mimicry.

Language: Английский

The Rapidly Changing Patterns in Bacterial Co-Infections Reveal Peaks in Limited Gram Negatives during COVID-19 and Their Sharp Drop Post-Vaccination, Implying Potential Evolution of Co-Protection during Vaccine–Virus–Bacterial Interplay DOI Creative Commons
Kamaleldin B. Said, Ahmed Alsolami, Khalid Farhan Alshammari

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(2), P. 227 - 227

Published: Jan. 31, 2024

SARS-CoV-2 has caused the most devastating pandemic of all time in recent human history. However, there is a serious paucity high-quality data on aggravating factors and mechanisms co-infection. This study aimed to identify trending patterns bacterial co-infections types associated outcomes three phases pandemic. Using quality hospital data, we have investigated fatality rates, profiles, before, during, after COVID-19 vaccination. Out 389 isolates used different aspects, 298 were examined before during (n = 149 n during). In this group, death rates 32% compared only 7.4% with significant association (p-value 0.000000075). rate was 34% co-infected 170) non-co-infected patients 128), indicating highly value 0.00000000000088). analysis without other respiratory problems 28) indicated that among remaining 270 patients, occurred 30% 150) 0.8% 120) high p-value 0.00000000076. The vaccination showed decline Staphylococcus aureus concomitant peaks Gram negatives before/n including Klebsiella pneumonian 11/49 before/during, E. coli 10/24, A. baumannii 8/25, Ps. aeruginosa 5/16, S. 13/1. Nevertheless, post-vaccination phase 91), gender-specific for potential differences susceptibility. Methicillin-resistant dominated both genders followed by males females, latter gender showing higher isolations species. pneumoniae declined third place male patients. drastic K. strongly implied co-protection vaccines. Future would gain more insights into molecular mimicry.

Language: Английский

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