Unveiling the cell biology of hippocampal neurons with dendritic axon origin

The Journal of Cell Biology, Journal Year: 2024, Volume and Issue: 224(1)

Published: Sept. 24, 2024

In mammalian axon-carrying–dendrite (AcD) neurons, the axon emanates from a basal dendrite, instead of soma, to create privileged route for action potential generation at initial segment (AIS). However, it is unclear how such unusual morphology established and whether structure function AIS in AcD neurons are preserved. By using dissociated hippocampal cultures as model, we show that development can occur prior synaptogenesis independently vivo environment. A single precursor neurite first gives rise then AcD. The possesses similar cytoskeletal architecture soma-derived similarly functions trafficking barrier retain axon-specific molecular composition. does not undergo homeostatic plasticity, contains lesser cisternal organelles, receives fewer inhibitory inputs. Our findings reveal insights into neuron biology underscore structural differences based on onset.

Language: Английский

Increased Interhemispheric Connectivity of a Distinct Type of Hippocampal Pyramidal Cells

Journal of Neuroscience, Journal Year: 2023, Volume and Issue: 44(7), P. e0440232023 - e0440232023

Published: Dec. 12, 2023

Neurons typically generate action potentials at their axon initial segment based on the integration of synaptic inputs. In many neurons, extends from soma, equally weighting dendritic A notable exception is found in a subset hippocampal pyramidal cells where emerges basal dendrite. This structure allows these axon-carrying dendrites (AcDs) privileged input route. We that male mice, such CA1 region receive stronger excitatory contralateral CA3, compared with those somatic origins. supported by higher count putative synapses CA3 AcD. These findings, combined prior observations distinct role sharp-wave ripple firing, suggest key this neuron coordinating bi-hemispheric activity during memory-centric oscillations.

Language: Английский