Transcutaneous Vagus Nerve Stimulation Boosts Post-Error Accuracy During Perceptual Decision-Making DOI Creative Commons
Shiyong Su,

Thomas Vanvoorden,

Pierre Le Denmat

et al.

Published: Oct. 22, 2024

Abstract The locus coeruleus-norepinephrine (LC-NE) system is a well-established regulator of behavior, yet its precise role remains unclear. Animal studies predominantly support “gain” hypothesis, suggesting that the LC-NE enhances sensory processing, while human have proposed an alternative “urgency” postulating primarily accelerates responses. To address this discrepancy, we administered transcutaneous vagus nerve stimulation (tVNS) in two experiments involving 43 participants. In first experiment, showed 4-second tVNS trains reliably induced greater pupil dilation compared to SHAM condition, indicating increased activity. second applied during random dot motion task assess impact on perceptual decision-making. Notably, improved accuracy without affecting reaction times, which appears inconsistent with hypothesis. Drift-diffusion model analyses further supported revealing drift rate, indicative enhanced evidence accumulation. Accuracy and drift-rate improvements were especially pronounced following errors less proficient participants, who otherwise exhibited post-error declines these measures under condition. Our findings suggest influence adapts demands, becoming beneficial challenging contexts. Overall, study underscores potential as non-invasive tool investigate causal behavior.

Language: Английский

Transcutaneous Vagus Nerve Stimulation Boosts Post-Error Accuracy During Perceptual Decision-Making DOI Creative Commons
Shiyong Su,

Thomas Vanvoorden,

Pierre Le Denmat

et al.

Published: Oct. 22, 2024

Abstract The locus coeruleus-norepinephrine (LC-NE) system is a well-established regulator of behavior, yet its precise role remains unclear. Animal studies predominantly support “gain” hypothesis, suggesting that the LC-NE enhances sensory processing, while human have proposed an alternative “urgency” postulating primarily accelerates responses. To address this discrepancy, we administered transcutaneous vagus nerve stimulation (tVNS) in two experiments involving 43 participants. In first experiment, showed 4-second tVNS trains reliably induced greater pupil dilation compared to SHAM condition, indicating increased activity. second applied during random dot motion task assess impact on perceptual decision-making. Notably, improved accuracy without affecting reaction times, which appears inconsistent with hypothesis. Drift-diffusion model analyses further supported revealing drift rate, indicative enhanced evidence accumulation. Accuracy and drift-rate improvements were especially pronounced following errors less proficient participants, who otherwise exhibited post-error declines these measures under condition. Our findings suggest influence adapts demands, becoming beneficial challenging contexts. Overall, study underscores potential as non-invasive tool investigate causal behavior.

Language: Английский

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