Tracking of Ubiquitin Signaling through 3.5 Billion Years of Combinatorial Conjugation DOI Open Access

A. N. Kaminskaya,

A. S. Evpak, Alexey A. Belogurov

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8671 - 8671

Published: Aug. 8, 2024

Ubiquitination is an evolutionary, ancient system of post-translational modification proteins that occurs through a cascade involving ubiquitin activation, transfer, and conjugation. The maturation this has followed two main pathways. first the conservation universal structural fold ubiquitin-like proteins, which are present in both Archaea Bacteria, as well multicellular Eukaryotes. second rise complexity superfamily ligases, conjugate to substrates, terms increase number enzyme variants, greater variation organization, diversification their catalytic domains. Here, we examine diversity ubiquitination among different organisms, assessing variety key domains enzymes itself. Our data show E2 ubiquitin-conjugating metazoan phyla highly conservative, whereas homology E3 ligases with human orthologues gradually decreases depending on “molecular clock” timing evolutionary distance. Surprisingly, Chordata Echinodermata, diverged over 0.5 billion years ago during Cambrian explosion, share almost same humans amino acid sequences but not adaptor proteins. These observations may suggest that, firstly, already existed its current form last common ancestor was generally affected by purifying selection metazoans. Secondly, it indicate convergent evolution highlight “upper deck” system, plays crucial role chordate evolution.

Language: Английский

Conservation and similarity of bacterial and eukaryotic innate immunity DOI
Hannah E. Ledvina, Aaron T. Whiteley

Nature Reviews Microbiology, Journal Year: 2024, Volume and Issue: 22(7), P. 420 - 434

Published: Feb. 28, 2024

Language: Английский

Citations

24
Innate immunity: the bacterial connection DOI Open Access
François Rousset

Trends in Immunology, Journal Year: 2023, Volume and Issue: 44(12), P. 945 - 953

Published: Nov. 1, 2023

Language: Английский

Citations

11
Multi-conflict islands are a widespread trend withinSerratiaspp DOI Creative Commons

Thomas Cummins,

S Garrett, Tim R. Blower

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 28, 2024

SUMMARY Bacteria carry numerous anti-phage systems in ‘defence islands’ or hotspots. Recent studies have delineated the content and boundaries of these islands various species, revealing instances that encode additional factors, including antibiotic resistance, stress genes, Type VI Secretion System (T6SS)-dependent effectors, virulence factors. Our study identifies three defence Serratia genus with a mixed cargo systems, factors different types anti-bacterial modules, widespread trend co-accumulation extends beyond T6SS-dependent effectors to colicins contact-dependent inhibition systems. We report identification four distinct system/subtypes, previously unreported Toll/IL-1 receptor (TIR)-domain-containing system population-wide immunity, two loci co-opting predicted T6SS-related protein for phage defence. This enhances our understanding domains can be co-opted diverse combinations which known proteins assembled, resulting highly diversified arsenal.

Language: Английский

Citations

0
Tracking of Ubiquitin Signaling through 3.5 Billion Years of Combinatorial Conjugation DOI Open Access

A. N. Kaminskaya,

A. S. Evpak, Alexey A. Belogurov

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8671 - 8671

Published: Aug. 8, 2024

Ubiquitination is an evolutionary, ancient system of post-translational modification proteins that occurs through a cascade involving ubiquitin activation, transfer, and conjugation. The maturation this has followed two main pathways. first the conservation universal structural fold ubiquitin-like proteins, which are present in both Archaea Bacteria, as well multicellular Eukaryotes. second rise complexity superfamily ligases, conjugate to substrates, terms increase number enzyme variants, greater variation organization, diversification their catalytic domains. Here, we examine diversity ubiquitination among different organisms, assessing variety key domains enzymes itself. Our data show E2 ubiquitin-conjugating metazoan phyla highly conservative, whereas homology E3 ligases with human orthologues gradually decreases depending on “molecular clock” timing evolutionary distance. Surprisingly, Chordata Echinodermata, diverged over 0.5 billion years ago during Cambrian explosion, share almost same humans amino acid sequences but not adaptor proteins. These observations may suggest that, firstly, already existed its current form last common ancestor was generally affected by purifying selection metazoans. Secondly, it indicate convergent evolution highlight “upper deck” system, plays crucial role chordate evolution.

Language: Английский

Citations

0