Virological characteristics of the SARS-CoV-2 BA.2.86 variant

Cell Host & Microbe, Journal Year: 2024, Volume and Issue: 32(2), P. 170 - 180.e12

Published: Jan. 26, 2024

In late 2023, several SARS-CoV-2 XBB descendants, notably EG.5.1, were predominant worldwide. However, a distinct lineage, the BA.2.86 variant, also emerged. is phylogenetically from other Omicron sublineages, accumulating over 30 amino acid mutations in its spike protein. Here, we examined virological characteristics of variant. Our epidemic dynamics modeling suggested that relative reproduction number significantly higher than EG.5.1. Additionally, four clinically available antivirals effective against BA.2.86. Although fusogenicity similar to parental BA.2 spike, intrinsic pathogenicity hamsters was lower BA.2. Since growth kinetics are those both vitro and vivo, attenuated likely due decreased replication capacity. These findings uncover features BA.2.86, providing insights for control treatment.

Language: Английский

SARS-CoV-2 inactivation: assessing the efficacy of GO-anchored filters versus various commercial masks

RSC Applied Interfaces, Journal Year: 2024, Volume and Issue: 1(3), P. 573 - 579

Published: Jan. 1, 2024

GO-anchored filter shows enhanced anti-SARS-CoV-2 properties compared to commercially available face masks. The current findings imply the potential of GO in field virus inactivation and personal protective equipment such as

Language: Английский