Genomic consequences of isolation and inbreeding in an island dingo population DOI Creative Commons
Ana V. Leon-Apodaca, Manoharan Kumar,

Andres del Castillo

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 15, 2023

ABSTRACT Dingoes come from an ancient canid lineage that originated in East Asia around 8000-11,000 years BP. As Australia’s largest terrestrial predator, dingoes play important ecological role. A small, protected population exists on a world heritage listed offshore island, K’gari (formerly Fraser Island). Concern regarding the persistence of has risen due to their low genetic diversity and elevated inbreeding levels. However, whole-genome sequencing data is lacking this population. Here, we include five new sequences dingoes. We analyze total 18 whole genome sampled mainland Australia assess genomic consequences demographic histories. Long (>1 Mb) runs homozygosity (ROH) — indicators are all showed significantly higher levels very long ROH (>5 Mb), providing evidence for small size, isolation, inbreeding, strong founder effect. Our results suggest that, despite current purging strongly deleterious mutations, which, absence further reductions may facilitate populations isolation. there be little no mildly alleles, which have long-term consequences, should considered by conservation management programs. SIGNIFICANCE long-standing question genetics whether isolation always leads inevitable extinction. Here conduct first-ever analysis living island off coast (K’gari). show these animals beset diversity, likely result extensive number homozygotes. our highly allowed them persist term extremely (<200 individuals).

Language: Английский

Pervasive selective sweeps across human gut microbiomes DOI Creative Commons

Richard Wolff,

Nandita R. Garud

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 23, 2023

The human gut microbiome is composed of a highly diverse consortia species which are continually evolving within and across hosts. ability to identify adaptations common many microbiomes would not only reveal shared selection pressures hosts, but also key drivers functional differentiation the that may affect community structure host traits. However, date there has been systematic scan for have spread microbiomes. Here, we develop novel statistic named integrated Linkage Disequilibrium Score (iLDS) can detect adaptive haplotypes via migration horizontal gene transfer. Specifically, iLDS leverages signals hitchhiking deleterious variants with beneficial variant. Application

Language: Английский

Citations

6
Genomic consequences of isolation and inbreeding in an island dingo population DOI Creative Commons
Ana V. Leon-Apodaca, Manoharan Kumar,

Andres del Castillo

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 15, 2023

ABSTRACT Dingoes come from an ancient canid lineage that originated in East Asia around 8000-11,000 years BP. As Australia’s largest terrestrial predator, dingoes play important ecological role. A small, protected population exists on a world heritage listed offshore island, K’gari (formerly Fraser Island). Concern regarding the persistence of has risen due to their low genetic diversity and elevated inbreeding levels. However, whole-genome sequencing data is lacking this population. Here, we include five new sequences dingoes. We analyze total 18 whole genome sampled mainland Australia assess genomic consequences demographic histories. Long (>1 Mb) runs homozygosity (ROH) — indicators are all showed significantly higher levels very long ROH (>5 Mb), providing evidence for small size, isolation, inbreeding, strong founder effect. Our results suggest that, despite current purging strongly deleterious mutations, which, absence further reductions may facilitate populations isolation. there be little no mildly alleles, which have long-term consequences, should considered by conservation management programs. SIGNIFICANCE long-standing question genetics whether isolation always leads inevitable extinction. Here conduct first-ever analysis living island off coast (K’gari). show these animals beset diversity, likely result extensive number homozygotes. our highly allowed them persist term extremely (<200 individuals).

Language: Английский

Citations

1