Relating sex-bias in human cortical and hippocampal microstructure to sex hormones DOI Creative Commons
Svenja Küchenhoff, Şeyma Bayrak, Rachel G. Zsido

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 23, 2024

Abstract Determining sex-bias in brain structure is of great societal interest to improve diagnostics and treatment brain-related disorders. So far, studies on predominantly focus macro-scale measures, often ignore factors determining this bias. Here we study cortical hippocampal microstructure relation sex hormones. Investigating quantitative intracortical profiling in-vivo using the T1w/T2w ratio 1093 healthy females males cross-sectional Human Connectome Project young adult sample, find that regional differs between effect size varies depending self-reported hormonal status females. Microstructural expression hormone genes, based an independent post-mortem are spatially coupled. Lastly, most pronounced paralimbic areas, with low laminar complexity, which predicted be plastic their cytoarchitectural properties. Albeit correlative, our underscores importance incorporating variables into investigation plasticity.

Language: Английский

Relating sex-bias in human cortical and hippocampal microstructure to sex hormones DOI Creative Commons
Svenja Küchenhoff, Şeyma Bayrak, Rachel G. Zsido

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 23, 2024

Abstract Determining sex-bias in brain structure is of great societal interest to improve diagnostics and treatment brain-related disorders. So far, studies on predominantly focus macro-scale measures, often ignore factors determining this bias. Here we study cortical hippocampal microstructure relation sex hormones. Investigating quantitative intracortical profiling in-vivo using the T1w/T2w ratio 1093 healthy females males cross-sectional Human Connectome Project young adult sample, find that regional differs between effect size varies depending self-reported hormonal status females. Microstructural expression hormone genes, based an independent post-mortem are spatially coupled. Lastly, most pronounced paralimbic areas, with low laminar complexity, which predicted be plastic their cytoarchitectural properties. Albeit correlative, our underscores importance incorporating variables into investigation plasticity.

Language: Английский

Citations

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