The Transmitter, Journal Year: 2023, Volume and Issue: unknown
Published: Jan. 1, 2023
Language: Английский
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 23, 2024
ABSTRACT The immune and sensory nervous systems, having evolved together, use a shared language of receptors transmitters to maintain homeostasis by responding external internal disruptions. Although beneficial in many cases, neurons can exacerbate inflammation during allergic reactions, such as asthma. Our research modeled asthma aggravated pollution, exposing mice ambient PM 2.5 particles ovalbumin. This exposure significantly increased bronchoalveolar lavage fluid neutrophils γδ T cells compared ovalbumin alone. We normalized airway lung neutrophil levels silencing nociceptor at inflammation’s peak using intranasal QX-314 or ablating TRPV1-expressing neurons. Additionally, we observed heightened sensitivity chemical-sensing TRPA1 channels from pollution-exacerbated asthmatic mice. Elevated artemin were detected the pollution-exposed mice, with normalizing ablated Upon particles, alveolar macrophages expressing pollution-sensing aryl hydrocarbon receptors, identified source artemin. molecule enhanced responsiveness influx, providing novel mechanism which lung-innervating respond air pollution suggesting potential therapeutic target for controlling neutrophilic asthma, clinically intractable condition.
Language: Английский
Citations
0
Published: Jan. 1, 2024
Language: Английский
Citations
0
Published: Oct. 21, 2024
The immune and sensory nervous systems, having evolved together, use a shared language of receptors transmitters to maintain homeostasis by responding external internal disruptions. Although beneficial in many cases, neurons can exacerbate inflammation during allergic reactions, such as asthma. Our research modeled asthma aggravated pollution, exposing mice ambient PM 2.5 particles ovalbumin. This exposure significantly increased bronchoalveolar lavage fluid neutrophils γδ T cells compared ovalbumin alone. We normalized airway lung neutrophil levels silencing nociceptor at inflammation’s peak using intranasal QX-314 or ablating TRPV1-expressing neurons. Additionally, we observed heightened sensitivity chemical-sensing TRPA1 channels from pollution-exacerbated asthmatic mice. Elevated artemin were detected the pollution-exposed mice, with normalizing ablated Upon particles, alveolar macrophages expressing pollution-sensing aryl hydrocarbon receptors, identified source artemin. molecule enhanced responsiveness influx, providing novel mechanism which lung-innervating respond air pollution suggesting potential therapeutic target for controlling neutrophilic asthma, clinically intractable condition.
Language: Английский
Citations
0
Published: Oct. 21, 2024
The immune and sensory nervous systems, having evolved together, use a shared language of receptors transmitters to maintain homeostasis by responding external internal disruptions. Although beneficial in many cases, neurons can exacerbate inflammation during allergic reactions, such as asthma. Our research modeled asthma aggravated pollution, exposing mice ambient PM 2.5 particles ovalbumin. This exposure significantly increased bronchoalveolar lavage fluid neutrophils γδ T cells compared ovalbumin alone. We normalized airway lung neutrophil levels silencing nociceptor at inflammation’s peak using intranasal QX-314 or ablating TRPV1-expressing neurons. Additionally, we observed heightened sensitivity chemical-sensing TRPA1 channels from pollution-exacerbated asthmatic mice. Elevated artemin were detected the pollution-exposed mice, with normalizing ablated Upon particles, alveolar macrophages expressing pollution-sensing aryl hydrocarbon receptors, identified source artemin. molecule enhanced responsiveness influx, providing novel mechanism which lung-innervating respond air pollution suggesting potential therapeutic target for controlling neutrophilic asthma, clinically intractable condition.
Language: Английский
Citations
0
The Transmitter, Journal Year: 2023, Volume and Issue: unknown
Published: Jan. 1, 2023
Language: Английский
Citations
0