Transposable element small and long RNAs in aging brains and implications in Huntington's and Parkinson's disease DOI Open Access
Gargi Dayama, Shruti Gupta, Brianne K. Connizzo

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 25, 2024

ABSTRACT Transposable Elements (TEs) are implicated in aging and neurodegenerative disorders, but the impact of brain TE RNA dynamics on these phenomena is not fully understood. Therefore, we quantified changes post-mortem human mouse brains disorders Huntington’s Disease (HD) Parkinson’s (PD). We tracked small RNAs (smRNAs) expression landscape to assess relationship active processing from long (lnRNAs). Human transcriptomes BrainSpan Atlas displayed a significant shift smRNA patterns at age 20 years, whereas lacked any such marked change, despite clear aging-associated mRNA levels. frontal cortex pronounced sense smRNAs during with negative between lnRNAs indicative associated regulatory effects. Our analysis revealed dysregulation HD, while PD showed stronger lnRNAs, potentially correlating early average death for HD relative PD. Furthermore, TE-silencing factor TRIM28 was down-regulated only brains, possibly explaining lack substantial brains. study suggests may serve as novel biomarkers disorders.

Language: Английский

Transposable element small and long RNAs in aging brains and implications in Huntington's and Parkinson's disease DOI Open Access
Gargi Dayama, Shruti Gupta, Brianne K. Connizzo

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 25, 2024

ABSTRACT Transposable Elements (TEs) are implicated in aging and neurodegenerative disorders, but the impact of brain TE RNA dynamics on these phenomena is not fully understood. Therefore, we quantified changes post-mortem human mouse brains disorders Huntington’s Disease (HD) Parkinson’s (PD). We tracked small RNAs (smRNAs) expression landscape to assess relationship active processing from long (lnRNAs). Human transcriptomes BrainSpan Atlas displayed a significant shift smRNA patterns at age 20 years, whereas lacked any such marked change, despite clear aging-associated mRNA levels. frontal cortex pronounced sense smRNAs during with negative between lnRNAs indicative associated regulatory effects. Our analysis revealed dysregulation HD, while PD showed stronger lnRNAs, potentially correlating early average death for HD relative PD. Furthermore, TE-silencing factor TRIM28 was down-regulated only brains, possibly explaining lack substantial brains. study suggests may serve as novel biomarkers disorders.

Language: Английский

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