Exploring sex-specific neuroendocrine influences on the sensorimotor-association axis in single individuals DOI Creative Commons

Bianca Serio,

Deniz Yılmaz, Laura Pritschet

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 5, 2024

Human neuroimaging studies consistently show multimodal patterns of variability along a key principle macroscale cortical organization - the sensorimotor-association (S-A) axis. However, little is known about day-to-day fluctuations in functional activity this axis within an individual, including sex-specific neuroendocrine factors contributing to such transient changes. We leveraged data from two densely sampled healthy young adults, one female and male, investigate intra-individual daily S-A axis, which we computed as our measure by reducing dimensionality connectivity matrices. Daily was greatest temporal limbic ventral prefrontal regions both participants, more strongly pronounced male subject. Next, probed local- system-level effects steroid hormones self-reported perceived stress on organization. Our findings revealed modest that differed between hinting at subtle -potentially sex-specific- associations In sum, study points possible modulators brain organization, highlighting need for further research larger samples.

Language: Английский

Microstructural asymmetry in the human cortex DOI Creative Commons
Bin Wan, Amin Saberi, Casey Paquola

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 9, 2024

Abstract While macroscale brain asymmetry and its relevance for human cognitive function have been consistently shown, the underlying neurobiological signatures remain an open question. Here, we probe layer-specific microstructural of cortex using intensity profiles from post-mortem cytoarchitecture. An anterior-posterior cortical pattern left-right was found, varying across layers. A similar observed in vivo imaging, with showing strongest similarity layer III. Microstructural varied as a age sex found to be heritable. Moreover, microstructure corresponded intrinsic function, particular sensory areas. Last, probing behavioral relevance, differential association language markers mental health asymmetry, illustrating functional divergence between inferior-superior axes anchored development. Our study highlights layer-based patterning relevance.

Language: Английский

Citations

1
Exploring sex-specific neuroendocrine influences on the sensorimotor-association axis in single individuals DOI Creative Commons

Bianca Serio,

Deniz Yılmaz, Laura Pritschet

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 5, 2024

Human neuroimaging studies consistently show multimodal patterns of variability along a key principle macroscale cortical organization - the sensorimotor-association (S-A) axis. However, little is known about day-to-day fluctuations in functional activity this axis within an individual, including sex-specific neuroendocrine factors contributing to such transient changes. We leveraged data from two densely sampled healthy young adults, one female and male, investigate intra-individual daily S-A axis, which we computed as our measure by reducing dimensionality connectivity matrices. Daily was greatest temporal limbic ventral prefrontal regions both participants, more strongly pronounced male subject. Next, probed local- system-level effects steroid hormones self-reported perceived stress on organization. Our findings revealed modest that differed between hinting at subtle -potentially sex-specific- associations In sum, study points possible modulators brain organization, highlighting need for further research larger samples.

Language: Английский

Citations

0