Early-life stress alters postnatal chromatin development in the nucleus accumbens
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 13, 2024
ABSTRACT
Early-life
stress
sensitizes
individuals
to
subsequent
stressors
increase
lifetime
risk
for
psychiatric
disorders.
Within
the
nucleus
accumbens
(NAc)
—
a
key
limbic
brain
region
early-life
both
cellular
and
transcriptional
response
later
stress.
However,
molecular
mechanisms
linking
initial
activation
of
neurons
by
with
continued
sensitivity
across
lifespan
are
poorly
understood.
Using
combination
activity-dependent
tagging
ATAC-sequencing
postnatal
development,
we
find
that
initially
opens
chromatin
in
stress-activated
cells
opening
predicts
gene
expression
adult
stress,
suggesting
epigenetic
priming
as
mechanism
sensitization.
Moreover,
accelerates
development
within
these
activated
cells,
H3K4me1
deposition
broadly
NAc
post-translational
histone
modification
associated
open
priming.
By
adulthood,
observe
remodeling
throughout
NAc,
indicating
effects
long-lasting
propagate
into
broader
cell
population.
Lastly,
through
viral-mediated
epigenome
editing
behavioral
quantification,
during
early
is
sufficient
mimic
prime
hypersensitivity
Together,
our
results
show
memory
encoded
at
an
level
changes
architecture.
This
constitutes
novel
biological
which
programs
lifelong
sensitivity.
Language: Английский
Early life adversity increases risk for chronic posttraumatic pain, data from humans and rodents
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 2, 2024
ABSTRACT
Traumatic
stress
exposures
(TSE)
are
common
in
life.
While
most
individuals
recover
following
a
TSE,
substantial
subset
develop
adverse
posttraumatic
neuropsychiatric
sequelae
such
as
chronic
musculoskeletal
pain
(CPMP).
Vulnerability
factors
for
CPMP
poorly
understood,
which
hinders
identification
of
high-risk
targeted
interventions.
One
known
vulnerability
factor
many
types
is
exposure
to
early
life
adversity
(ELA),
but
few
studies
have
assessed
whether
ELA
increases
risk
CPMP.
This
study
used
data
from
the
AURORA
study,
prospective
human
cohort
TSE
survivors,
test
hypothesis
that
In
addition,
secondary
analyses,
we
subtypes
(including
childhood
bullying)
were
predictive
and
rat
model
consisting
neonatal
limited
bedding
(NLB),
combined
with
single
prolonged
(SPS)
adulthood,
would
accurately
findings.
participants
(n=2,480),
using
multinomial
logistic
regression
modeling
four
identified
latent
classes,
found
increased
high
unremitting
class
(OR=1.047,
p
<0.001),
moderate
(OR=1.031,
recovery
(OR=1.018,
=0.004),
physical
abuse,
emotional
bullying
being
strongest
predictors
assignment.
Similarly,
male
female
Sprague
Dawley
rats,
comparison
SPS
alone
NLB
caused
baseline
sensitivity
mechanical
hypersensitivity
(F(11,197)=3.22,
<0.001).
Further
animals
humans
needed
understand
mechanisms
by
confers
Summary
associated
greater
duration
traumatic
during
adulthood.
Language: Английский
Understanding the intersection of prenatal alcohol exposure and postnatal adversity: A systematic review from a developmental psychopathology lens
Alcohol Clinical and Experimental Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 24, 2024
Abstract
Fetal
alcohol
spectrum
disorders
(FASD)
are
among
the
most
common
neurodevelopmental
disabilities.
Individuals
with
FASD
experience
postnatal
adversity
(PA;
i.e.,
child
maltreatment
or
other
potentially
traumatic
events)
at
exceedingly
high
rates.
This
is
connected
to
increased
internalizing
and
externalizing
symptomatology.
The
current
systematic
review
aimed
synthesize
literature
regarding
intersectionality
of
FASD/prenatal
exposure
(PAE)
utilizing
developmental
psychopathology
(DP)
framework.
Adhering
Preferred
Reporting
Items
for
Systematic
Reviews
Meta‐Analyses
(PRISMA)
standards,
identification
studies
through
PsycInfo,
PubMed,
Web
Science
was
conducted.
Primary
data
on
PAE,
adversity,
individual
functioning
(biological,
cognitive,
affective),
external
systems,
familial
cultural
contexts
were
extracted.
Furthermore,
quality
assessment
information
extracted
all
studies.
Thirty‐one
met
inclusion
criteria.
Overall,
individuals
a
weighted
mean
4.44
adverse
childhood
experiences.
Multifinality
in
outcomes
evident,
as
impact
mental
health,
cognitive
ability,
biological
processes.
Cultural
context
settings
contribute
risk
resilience
factors.
points
unique
strengths
areas
improvement
within
literature.
Aligning
DP
framework,
intersection
complex
impacts
various
Systems
add
this
complexity.
Intervention
development
taking
into
consideration
these
multiple
factors
necessary.
Language: Английский