Nuclear RNA: a transcription-dependent regulator of chromatin structure

Biochemical Society Transactions, Journal Year: 2024, Volume and Issue: 52(4), P. 1605 - 1615

Published: July 31, 2024

Although the majority of RNAs are retained in nucleus, their significance is often overlooked. However, it now becoming clear that nuclear RNA forms a dynamic structure through interacting with various proteins can influence three-dimensional chromatin. We review emerging evidence for mesh or gel, highlighting interplay between DNA, and RNA-binding (RBPs), assessing critical role protein governing chromatin architecture. also discuss proposed formation regulation gel transcriptional control. suggest may concentrate machinery either by direct binding inducing RBPs to form microphase condensates, nanometre sized membraneless structures distinct properties surrounding medium an enrichment particular macromolecules.

Language: Английский

Identifying the “stripe” transcription factors and cooperative binding related to DNA methylation

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: Oct. 5, 2024

Language: Английский