Differential effects of aging, Alzheimer’s pathology, andAPOE4on longitudinal functional connectivity and episodic memory in older adults DOI Creative Commons
Larissa Fischer, Jenna N. Adams, Eóin N. Molloy

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract INTRODUCTION Both aging and Alzheimer’s disease (AD) affect episodic memory networks. How this relates to region-specific early differences in functional connectivity (FC), however, remains unclear. METHODS We assessed resting-state FC strength the medial temporal lobe (MTL) - posteromedial cortex (PMC) prefrontal network cognition over two years cognitively normal older adults from PREVENT-AD cohort. RESULTS within PMC between posterior hippocampus inferomedial precuneus decreased “normal” (amyloid- tau-negative adults). Lower was associated with poorer longitudinal performance. Increasing anterior superior related higher baseline AD pathology. Higher differentially trajectories depending on APOE4 genotype. DISCUSSION Findings suggest differential effects of pathology FC. MTL-PMC hypoconnectivity cognitive decline. Furthermore, hyperconnectivity decline carriers. Graphical abstract. A) “Normal aging” is characterized by a decrease connectivity. B) Cognitively unimpaired more at (measured via cerebrospinal fluid) exhibit increase

Language: Английский

Differential effects of aging, Alzheimer’s pathology, andAPOE4on longitudinal functional connectivity and episodic memory in older adults DOI Creative Commons
Larissa Fischer, Jenna N. Adams, Eóin N. Molloy

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract INTRODUCTION Both aging and Alzheimer’s disease (AD) affect episodic memory networks. How this relates to region-specific early differences in functional connectivity (FC), however, remains unclear. METHODS We assessed resting-state FC strength the medial temporal lobe (MTL) - posteromedial cortex (PMC) prefrontal network cognition over two years cognitively normal older adults from PREVENT-AD cohort. RESULTS within PMC between posterior hippocampus inferomedial precuneus decreased “normal” (amyloid- tau-negative adults). Lower was associated with poorer longitudinal performance. Increasing anterior superior related higher baseline AD pathology. Higher differentially trajectories depending on APOE4 genotype. DISCUSSION Findings suggest differential effects of pathology FC. MTL-PMC hypoconnectivity cognitive decline. Furthermore, hyperconnectivity decline carriers. Graphical abstract. A) “Normal aging” is characterized by a decrease connectivity. B) Cognitively unimpaired more at (measured via cerebrospinal fluid) exhibit increase

Language: Английский

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