MAIT cell homing in intestinal homeostasis and inflammation

Science Advances, Journal Year: 2025, Volume and Issue: 11(6)

Published: Feb. 7, 2025

Mucosa-associated invariant T (MAIT) cells are a large population of unconventional widely distributed in the human gastrointestinal tract. Their homing to gut is central maintaining mucosal homeostasis and immunity. This review discusses potential mechanisms that guide MAIT intestinal mucosa during inflammation, emphasizing roles chemokines, chemokine receptors, tissue adhesion molecules. The influence microbiota on cell different regions also discussed. Last, we introduce how organoid technology offers potentially valuable approach advance our understanding by providing more physiologically relevant model mimics tissue. These models may enable detailed investigation gut-specific cells. By regulation gut, avenues for therapeutic interventions targeting inflammatory conditions such as bowel diseases (IBD) emerge.

Language: Английский

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Defenders or defectors: mucosal-associated invariant T cells in autoimmune diseases

Current Opinion in Immunology, Journal Year: 2025, Volume and Issue: 93, P. 102542 - 102542

Published: Feb. 27, 2025

Language: Английский

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Mucosal-Associated Invariant T (MAIT) Cell Differentiation and Function

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

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