The role of gene copy number variation in antimicrobial resistance in human fungal pathogens

npj Antimicrobials and Resistance, Journal Year: 2025, Volume and Issue: 3(1)

Published: Jan. 6, 2025

Faced with the burden of increasing resistance to antifungals in many fungal pathogens and constant emergence new drug-resistant strains, it is essential assess importance various mechanisms. Fungi have relatively plastic genomes can tolerate genomic copy number variation (CNV) caused by aneuploidy gene amplification or deletion. In cases, these changes lead adaptation stressful conditions, including those antifungal drugs. Here, we specifically examine contribution CNVs resistance. We undertook a thorough literature search, collecting reports CNV, classifying examples CNV-conferred into four main find that human pathogens, there little evidence plays major role compared other types mutations. discuss why might be underestimating their approaches being used study them.

Language: Английский

Recent Advances in High-Throughput Genetics in Fungi

Published: Jan. 1, 2024

Language: Английский