Developmental Biology, Journal Year: 2024, Volume and Issue: 516, P. 148 - 157
Published: Aug. 18, 2024
Apoptosis is a regulated cell death that depends on caspases. It has mainly been studied as mechanism for the removal of unwanted cells. However, apoptotic cells can induce fate or behavior changes their neighbors and thereby participate in development. Here, we address functions apoptosis during metamorphosis cnidarian Hydractinia symbiolongicarpus. We describe profile larva identify Caspase3/7a, but no other executioner caspases, essential this context. Using pharmacological genetic approaches, find required normal head Inhibition resulted defects morphogenesis. Neurogenesis was compromised body column apoptosis-inhibited animals there effect survival proliferation stem cells, suggesting cellular commitment rather than maintenance progenitors. Differential transcriptomic analysis identifies TRAF genes downregulated larvae functional experiments provide evidence they are Finally, major role regeneration animal, contrast to significance Hydra regeneration.
Language: Английский