Segregation Between an Ornamental and a Disease Driver Gene Provides Insights Into Pigment Cell Regulation DOI Creative Commons

Erika Soria,

Qiusheng Lu,

Will Boswell

et al.

Pigment Cell & Melanoma Research, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

ABSTRACT Genetic interactions are adaptive within a species. Hybridization can disrupt such species‐specific genetic and creates novel that alter the hybrid progeny overall fitness. Hybrid incompatibility, which refers to degenerative decrease survival sterility, is one of results from combining two diverged genomes in hybrids. The discovery spontaneous lethal tumorigenesis underlying select hybrids between Xiphophorus species showed pathological process result interactions. Such leading phenotype thought shield gene flow However, certain do not develop tumors. Here we report identification locus residing genome represses an oncogene different Our finding provides insights into normal pigment cell development, regulation molecular mechanism incompatibility.

Language: Английский

Complex structural variation and behavioral interactions underpin a balanced sexual mimicry polymorphism DOI Creative Commons
Tristram O. Dodge, Bernard Kim, John J. Baczenas

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 14, 2024

Summary How phenotypic diversity originates and persists within populations are classic puzzles in evolutionary biology. While polymorphisms hypothesized to be under balancing selection segregate many species, it remains rare for the genetic basis selective forces both known same trait, leading an incomplete understanding of classes polymorphisms. Here, we uncover architecture a balanced sexual mimicry polymorphism identify behavioral mechanisms that may involved its maintenance swordtail fish Xiphophorus birchmanni . We find ∼40% X. males develop “false gravid spot”, melanic pigmentation pattern mimics “pregnancy spot” associated with maturity female live-bearing fish. Using genome-wide association mapping, detect single intergenic region variation false spot, which is upstream kitlga , gene melanophore patterning. By performing long-read sequencing across populations, complex structural rearrangements between alternate alleles at this locus. The spot haplotype drives increased allele-specific expression provides mechanistic explanation abundance causes spot. studying social interactions laboratory nature, experience less aggression; however, they also receive attention from other disdained by females. These play role maintaining natural populations. speculate variants affecting regulation underappreciated driver diverse species.

Language: Английский

Citations

1
Segregation between an ornamental and a disease driver gene provides insights into pigment cell regulation DOI Open Access

Erika Soria,

Qiusheng Lu,

Will Boswell

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 22, 2024

Genetic interactions are adaptive within a species. Hybridization can disrupt such species-specific genetic and creates novel that alter the hybrid progeny overall fitness. Hybrid incompatibility, which refers to degenerative decrease survival, is one of results from combining two diverged genomes in hybrids. The discovery spontaneous lethal tumorigenesis underlying select hybrids between

Language: Английский

Citations

0
Molecular Systematics and Divergence of Tor and Neolissochilus Fishes (Cypriniforms: Cyprinidae) from Southeast Asia and South China DOI Creative Commons
Ling Wu, Tao QIN, Huy Duc Hoang

et al.

Journal of Zoological Systematics & Evolutionary Research, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

In Southeast Asia, mahseer fishes, such as the species of Tor and Neolissochilus , are significant native commercial fish. Their phylogeny categorization have a convoluted history. this study, molecular systematics divergence fishes from Asia South China were examined using partial or complete sequences four mitochondrial genes (cytochrome oxidase I, cytochrome b 16S, ND4). This study substantiated monophyly supported N. benasi an independent genus. The result T. laterivittatus synonym sinensis dongnaiensis tambra . addition, we presented high diversity crypticity these two taxa in Asia. divergent time estimation indicated originated early Miocene (about 16.73 Ma), genus other began at about 12.86 Ma.

Language: Английский

Citations

0
Segregation Between an Ornamental and a Disease Driver Gene Provides Insights Into Pigment Cell Regulation DOI Creative Commons

Erika Soria,

Qiusheng Lu,

Will Boswell

et al.

Pigment Cell & Melanoma Research, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

ABSTRACT Genetic interactions are adaptive within a species. Hybridization can disrupt such species‐specific genetic and creates novel that alter the hybrid progeny overall fitness. Hybrid incompatibility, which refers to degenerative decrease survival sterility, is one of results from combining two diverged genomes in hybrids. The discovery spontaneous lethal tumorigenesis underlying select hybrids between Xiphophorus species showed pathological process result interactions. Such leading phenotype thought shield gene flow However, certain do not develop tumors. Here we report identification locus residing genome represses an oncogene different Our finding provides insights into normal pigment cell development, regulation molecular mechanism incompatibility.

Language: Английский

Citations

0