Circatidal control of gene expression in the deep-sea hot vent shrimp Rimicaris leurokolos

Proceedings of the Royal Society B Biological Sciences, Journal Year: 2025, Volume and Issue: 292(2040)

Published: Feb. 1, 2025

Biological clocks are a ubiquitous feature of all life, enabling the use natural environmental cycles to track time. Although studies on circadian rhythms have contributed greatly knowledge chronobiology, biological in dark biospheres such as deep sea remain poorly understood. Here, based free-running experiment laboratory, we reveal potentially endogenous gene expression deep-sea hydrothermal vent shrimp Rimicaris leurokolos . Oscillations with approximately 12 h periods, probably reflecting tidal influence, prevail over others temporal transcriptome, indicating R. depends circatidal clock consisting at least some components independent from clocks. The transcripts exhibit an antiphased pattern divided into two internally synchronized clusters, correlated wide-ranging processes that occur nucleus and cytoplasm, respectively. In addition, showed great similarities genes fruit flies mice exhibiting ultradian rhythms, tide had broad impact evolution oscillations found across Metazoa. These findings not only provide new insights adaptations organisms but also highlight intriguing models for chronobiological studies, particularly those linked rhythms.

Language: Английский

Evidence for ~12-h ultradian gene programs in humans

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(1)

Published: Aug. 9, 2024

Mice and many marine organisms exhibit ~12-h ultradian rhythms, however, direct evidence of rhythms in humans is lacking. Here, we performed prospective, temporal transcriptome profiling peripheral white blood cells from three healthy humans. All participants independently exhibited robust transcriptional molecular programs involved RNA protein metabolism, with strong homology to circatidal gene previously identified Cnidarian species.

Language: Английский