Embracing variability in the search for biological mechanisms of psychiatric illness DOI Open Access
Ashlea Segal, Jeggan Tiego, Alexander Holmes

et al.

Published: June 25, 2024

Despite decades of research, we lack objective diagnostic or prognostic biomarkers mental health problems. A key reason for this limited progress is a reliance on the traditional case-control paradigm, which assumes that each disorder has single cause can be uncovered by comparing average phenotypic values cases and control samples. Here, discuss problematic assumptions paradigm based highlight recent efforts seek to characterize, rather than minimize, inherent clinical biological variability characterizes psychiatric populations. We argue embracing such will necessary understand pathophysiological mechanisms develop more targeted effective treatments.

Language: Английский

Embracing variability in the search for biological mechanisms of psychiatric illness DOI Open Access
Ashlea Segal, Jeggan Tiego, Alexander Holmes

et al.

Published: June 25, 2024

Despite decades of research, we lack objective diagnostic or prognostic biomarkers mental health problems. A key reason for this limited progress is a reliance on the traditional case-control paradigm, which assumes that each disorder has single cause can be uncovered by comparing average phenotypic values cases and control samples. Here, discuss problematic assumptions paradigm based highlight recent efforts seek to characterize, rather than minimize, inherent clinical biological variability characterizes psychiatric populations. We argue embracing such will necessary understand pathophysiological mechanisms develop more targeted effective treatments.

Language: Английский

Citations

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