Spike deep mutational scanning helps predict success of SARS-CoV-2 clades

Nature, Journal Year: 2024, Volume and Issue: 631(8021), P. 617 - 626

Published: July 3, 2024

SARS-CoV-2 variants acquire mutations in the spike protein that promote immune evasion

Language: Английский

Burden of Acute Respiratory Infections Caused by Influenza Virus, Respiratory Syncytial Virus, and SARS-CoV-2 with Consideration of Older Adults: A Narrative Review

Infectious Diseases and Therapy, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 30, 2024

Influenza virus, respiratory syncytial virus (RSV), and severe acute syndrome coronavirus 2 (SARS-CoV-2) are infections (ARIs) that can cause substantial morbidity mortality among at-risk individuals, including older adults. In this narrative review, we summarize themes identified in the literature regarding epidemiology, seasonality, immunity after infection, clinical presentation, transmission for these ARIs, along with impact of COVID-19 pandemic on seasonal patterns influenza RSV infections, consideration data specific to adults when available. As adult population increases globally, it is paramount importance fully characterize true disease burden ARIs order develop appropriate mitigation strategies minimize their vulnerable populations. Challenges associated characterizing diseases include shared symptomology presentation RSV, SARS-CoV-2, which complicate accurate diagnosis highlight need improved testing surveillance practices. To end, multiple regional, national, global virologic systems have been established provide knowledge viral support preparedness response potential outbreaks, help inform prevention reduce severity transmission. Beyond illness, long-term health consequences also result from SARS-CoV-2 infection. These cardiovascular pulmonary complications, worsening existing chronic conditions, increased frailty, reduced life expectancy. place a financial society healthcare systems. Collectively, indicate present challenge, underscoring interventions improve outcomes illnesses.Graphical abstract video available article.

Language: Английский

Engineering a SARS-CoV-2 vaccine targeting the RBD cryptic-face via immunofocusing

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 5, 2024

The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein is main target neutralizing antibodies. Although they are infrequently elicited during infection or vaccination, antibodies that bind to conformation-specific cryptic face RBD display remarkable breadth binding and neutralization across

Language: Английский