Chemosensory modulation of eye-body coordination in larval zebrafish DOI Creative Commons
Samuel K. H. Sy, Danny Cheuk Wing Chan,

Jenny J. Zhang

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 28, 2024

Abstract Coordinated eye-body movements are essential for many animal behaviors, yet the influence of chemosensory inputs on these remains underexplored. Here, we enhance Fish-On-Chips optofluidic platform to reveal that larval zebrafish use coupled saccade-tail flips avoidance, but not pursuit. Spontaneous saccades, which alternate in direction, closely synchronized with tail via anticipatory adjustments flip event rate, directionality, and kinematics. In response ethologically representative cues, this coordination is differentially modulated based valence. Aversive chemical cues increase saccade frequency proportion saccade-coupled flips, while also enhancing turning intent as coupling strengthens. Conversely, appetitive chemicals promote more sustained gliding without impacting saccades or their coupling. Brain-wide neuronal activity imaging reveals pallium, a cortical homolog teleosts, strongly represents sensorimotor transformation aversive cue-associated flips. Our findings underscore critical role regulating an early vertebrate species, highlighting deep evolutionary integration sensory optimize locomotion.

Language: Английский

Chemosensory modulation of eye-body coordination in larval zebrafish DOI Creative Commons
Samuel K. H. Sy, Danny Cheuk Wing Chan,

Jenny J. Zhang

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 28, 2024

Abstract Coordinated eye-body movements are essential for many animal behaviors, yet the influence of chemosensory inputs on these remains underexplored. Here, we enhance Fish-On-Chips optofluidic platform to reveal that larval zebrafish use coupled saccade-tail flips avoidance, but not pursuit. Spontaneous saccades, which alternate in direction, closely synchronized with tail via anticipatory adjustments flip event rate, directionality, and kinematics. In response ethologically representative cues, this coordination is differentially modulated based valence. Aversive chemical cues increase saccade frequency proportion saccade-coupled flips, while also enhancing turning intent as coupling strengthens. Conversely, appetitive chemicals promote more sustained gliding without impacting saccades or their coupling. Brain-wide neuronal activity imaging reveals pallium, a cortical homolog teleosts, strongly represents sensorimotor transformation aversive cue-associated flips. Our findings underscore critical role regulating an early vertebrate species, highlighting deep evolutionary integration sensory optimize locomotion.

Language: Английский

Citations

0