Cellular evolution of the hypothalamic preoptic area of behaviorally divergent deer mice DOI Open Access
Jenny Chen, P. R. K. Richardson, Christopher Kirby

et al.

Published: Nov. 18, 2024

Genetic variation is known to contribute the of animal social behavior, but molecular mechanisms that lead behavioral differences are still not fully understood. Here, we investigate cellular evolution hypothalamic medial preoptic area (MPOA), a brain region plays critical role in across two sister species deer mice ( Peromyscus maniculatus and P. polionotus ) with divergent systems. These exhibit large mating parental care behavior sex. Using single-nucleus RNA-sequencing, build atlas MPOA for males females both species. We identify four cell types differentially abundant species, which may account behavior. Our data further implicate sex-biased be important sex-specific Finally, show remarkable reduction gene expression , monogamous also exhibits reduced sexual dimorphism powerful resource how neuronal traits evolving give rise innate

Language: Английский

Medial preoptic circuits governing instinctive social behaviors DOI Creative Commons

Tamás Láng,

Diána Dimén,

Szilvia Oláh

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(7), P. 110296 - 110296

Published: June 19, 2024

The medial preoptic area (MPOA) has long been implicated in maternal and male sexual behavior. Modern neuroscience methods have begun to reveal the cellular networks responsible, while also implicating MPOA other social behaviors, affiliative touch, aggression. interactions rely on input from conspecifics whose most important modalities rodents are olfaction somatosensation. These inputs bypass cerebral cortex reach influence function. Hormonal directly act neurons. In turn, controls responses via various projections for reward motor output. thus emerges as one of major brain centers instinctive While key elements circuits identified, a synthesis these new data is now provided further studies mechanisms by which interactions.

Language: Английский

Citations

3
Cellular evolution of the hypothalamic preoptic area of behaviorally divergent deer mice DOI Open Access
Jenny Chen, P. R. K. Richardson, Christopher Kirby

et al.

Published: Feb. 27, 2025

Genetic variation is known to contribute the of animal social behavior, but molecular mechanisms that lead behavioral differences are still not fully understood. Here, we investigate cellular evolution hypothalamic preoptic area (POA), a brain region plays critical role in across two sister species deer mice ( Peromyscus maniculatus and P. polionotus ) with divergent systems. These exhibit large mating parental care behavior sex. Using single-nucleus RNA-sequencing, build atlas POA for males females both species. We identify four cell types differentially abundant species, which may account based on functions these types. Our data further implicate sex-biased be important sex-specific behavior. Finally, show remarkable reduction gene expression , monogamous also exhibits reduced sexual dimorphism powerful resource how neuronal traits evolving give rise innate

Language: Английский

Citations

0
Cellular evolution of the hypothalamic preoptic area of behaviorally divergent deer mice DOI Creative Commons
Jenny Chen, P. R. K. Richardson, Christopher Kirby

et al.

eLife, Journal Year: 2025, Volume and Issue: 13

Published: April 7, 2025

Genetic variation is known to contribute the of animal social behavior, but molecular mechanisms that lead behavioral differences are still not fully understood. Here, we investigate cellular evolution hypothalamic preoptic area (POA), a brain region plays critical role in across two sister species deer mice ( Peromyscus maniculatus and P. polionotus ) with divergent systems. These exhibit large mating parental care behavior sex. Using single-nucleus RNA-sequencing, build atlas POA for males females both species. We identify four cell types differentially abundant species, which may account based on functions these types. Our data further implicate sex-biased be important sex-specific behavior. Finally, show remarkable reduction gene expression , monogamous also exhibits reduced sexual dimorphism powerful resource how neuronal traits evolving give rise innate

Language: Английский

Citations

0
Cellular evolution of the hypothalamic preoptic area of behaviorally divergent deer mice DOI Open Access
Jenny Chen, P. R. K. Richardson, Christopher Kirby

et al.

Published: Nov. 18, 2024

Genetic variation is known to contribute the of animal social behavior, but molecular mechanisms that lead behavioral differences are still not fully understood. Here, we investigate cellular evolution hypothalamic preoptic area (POA), a brain region plays critical role in across two sister species deer mice ( Peromyscus maniculatus and P. polionotus ) with divergent systems. These exhibit large mating parental care behavior sex. Using single-nucleus RNA-sequencing, build atlas POA for males females both species. We identify four cell types differentially abundant species, which may account based on functions these types. Our data further implicate sex-biased be important sex-specific behavior. Finally, show remarkable reduction gene expression , monogamous also exhibits reduced sexual dimorphism powerful resource how neuronal traits evolving give rise innate

Language: Английский

Citations

2
The Neurobiology of Parenting and Infant-Evoked Aggression DOI
Harris S. Kaplan, Patricia M. Horvath, Mohammed Mostafizur Rahman

et al.

Physiological Reviews, Journal Year: 2024, Volume and Issue: 105(1), P. 315 - 381

Published: Aug. 15, 2024

Parenting behavior comprises a variety of adult-infant and adult-adult interactions across multiple timescales. The state transition from nonparent to parent requires an extensive reorganization individual priorities physiology is facilitated by combinatorial hormone action on specific cell types that are integrated throughout interconnected brainwide neuronal circuits. In this review, we take comprehensive approach integrate historical current literature each these topics species, with focus rodents. New emerging molecular, circuit-based, computational technologies have recently been used address outstanding gaps in our framework knowledge infant-directed behavior. This work raising fundamental questions about the interplay between instinctive learned components parenting mutual regulation affiliative versus agonistic behaviors health disease. Whenever possible, point how helped gain novel insights opened new avenues research into neurobiology parenting. We hope review will serve as introduction for those field, resource already studying parenting, guidepost designing future studies.

Language: Английский

Citations

1
Cellular evolution of the hypothalamic preoptic area of behaviorally divergent deer mice DOI Creative Commons
Jenny Chen, P. R. K. Richardson, Christopher Kirby

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 26, 2024

Genetic variation is known to contribute the of animal social behavior, but molecular mechanisms that lead behavioral differences are still not fully understood. Here, we investigate cellular evolution hypothalamic medial preoptic area (MPOA), a brain region plays critical role in across two sister species deer mice (Peromyscus maniculatus and P. polionotus) with divergent systems. These exhibit large mating parental care behavior sex. Using single-nucleus RNA-sequencing, build atlas MPOA for males females both Peromyscus species. We identify four cell types differentially abundant species, which may account behavior. Our data further implicate sex-biased be important sex-specific Finally, show remarkable reduction gene expression polionotus, monogamous also exhibits reduced sexual dimorphism powerful resource how neuronal traits evolving give rise innate

Language: Английский

Citations

1
Kinesin motor KIF16A regulates microtubule stability and actin‐dependent spindle migration in mouse oocyte meiosis DOI Creative Commons

Wei Wang,

Zhenhu Shi,

D. Zhang

et al.

The FASEB Journal, Journal Year: 2024, Volume and Issue: 38(13)

Published: June 18, 2024

Kif16A, a member of the kinesin-3 family motor proteins, has been shown to play crucial roles in inducing mitotic arrest, apoptosis, and cell death. However, its during oocyte meiotic maturation have not fully defined. In this study, we report that Kif16A exhibits unique accumulation on spindle apparatus colocalizes with microtubule fibers mouse maturation. Targeted depletion using gene-targeting siRNA disrupts progression cycle. Furthermore, leads aberrant assembly chromosome misalignment oocytes. Our findings also indicate reduces tubulin acetylation levels compromises resistance depolymerizing drugs, suggesting role stability maintenance. Notably, find results notably elevated incidence defective kinetochore-microtubule attachments absence BubR1 localization at kinetochores, critical for activation checkpoint (SAC) activity. Additionally, observe is indispensable proper actin filament distribution, thereby impacting migration. summary, our demonstrate plays pivotal regulating dynamics ensuring both migration

Language: Английский

Citations

0
Cellular evolution of the hypothalamic preoptic area of behaviorally divergent deer mice DOI Open Access
Jenny Chen, P. R. K. Richardson, Christopher Kirby

et al.

Published: Nov. 18, 2024

Genetic variation is known to contribute the of animal social behavior, but molecular mechanisms that lead behavioral differences are still not fully understood. Here, we investigate cellular evolution hypothalamic medial preoptic area (MPOA), a brain region plays critical role in across two sister species deer mice ( Peromyscus maniculatus and P. polionotus ) with divergent systems. These exhibit large mating parental care behavior sex. Using single-nucleus RNA-sequencing, build atlas MPOA for males females both species. We identify four cell types differentially abundant species, which may account behavior. Our data further implicate sex-biased be important sex-specific Finally, show remarkable reduction gene expression , monogamous also exhibits reduced sexual dimorphism powerful resource how neuronal traits evolving give rise innate

Language: Английский

Citations

0