A thalamic perspective of (un)consciousness in pharmacological and pathological states in humans DOI Creative Commons

Dorottya Szocs,

Dian Lyu, Andrea I. Luppi

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 31, 2024

Summary Currently, there is substantial ongoing discussion around the functional role of thalamus in consciousness. What missing literature, however, a systematic investigation relevance specific thalamic nuclei pharmacologically and pathologically altered states consciousness humans. Using neuroimaging both healthy anaesthetised volunteers patients with disorders (DOC), we sought to identify which subregions cohorts may be differentially significant for loss Our findings revealed that pulvinar (Pu) ventral-latero-ventral (VLV) nuclei, anaesthesia, VLV, DOC, had distinct connectivity patterns related default mode somatomotor networks. Remarkably, among all Pu was found have strongest change anaesthetic-induced consciousness, while DOC patients, VLV comparison controls. Furthermore, provide evidence this neural biomarker also mirrors changes observed at behavioural level, could clinical implications targeted deep brain stimulation therapy DOC.

Language: Английский

Anesthesia and the neurobiology of consciousness DOI
George A. Mashour

Neuron, Journal Year: 2024, Volume and Issue: 112(10), P. 1553 - 1567

Published: April 4, 2024

Language: Английский

Citations

17
A thalamic perspective of (un)consciousness in pharmacological and pathological states in humans DOI Creative Commons

Dorottya Szocs,

Dian Lyu, Andrea I. Luppi

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 31, 2024

Summary Currently, there is substantial ongoing discussion around the functional role of thalamus in consciousness. What missing literature, however, a systematic investigation relevance specific thalamic nuclei pharmacologically and pathologically altered states consciousness humans. Using neuroimaging both healthy anaesthetised volunteers patients with disorders (DOC), we sought to identify which subregions cohorts may be differentially significant for loss Our findings revealed that pulvinar (Pu) ventral-latero-ventral (VLV) nuclei, anaesthesia, VLV, DOC, had distinct connectivity patterns related default mode somatomotor networks. Remarkably, among all Pu was found have strongest change anaesthetic-induced consciousness, while DOC patients, VLV comparison controls. Furthermore, provide evidence this neural biomarker also mirrors changes observed at behavioural level, could clinical implications targeted deep brain stimulation therapy DOC.

Language: Английский

Citations

0