Modeling the Neurocognitive Dynamics of Language across the Lifespan DOI Creative Commons
Clément Guichet, Sonja Banjac, Sophie Achard

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: July 4, 2023

Abstract Healthy aging is associated with a heterogeneous decline across cognitive functions, typically observed between language comprehension and production (LP). Examining resting-state fMRI neuropsychological data from 628 healthy adults (age 18-88) the CamCAN cohort, we performed state-of-the-art graph theoretical analysis to uncover neural mechanisms underlying this variability. At level, our findings suggest that LP not an isolated function but modulated throughout lifespan by extent of inter-cognitive synergy semantic domain-general processes. cerebral show DMN (Default Mode Network) suppression coupled FPN (Fronto-Parietal integration way for brain compensate effects dedifferentiation at minimal cost, efficiently mitigating age-related in LP. Relatedly, reduced midlife could compromise ability manage cost integration. This may prompt older adopt more cost-efficient compensatory strategy maintains global homeostasis expense performances. Taken together, propose represents critical neurocognitive juncture signifies onset decline, as gradually lose control over representations. We summarize novel SENECA model (Synergistic, Economical, Nonlinear, Emergent, Cognitive Aging), integrating connectomic dimensions within complex system perspective. Highlights Lexical ( ) relies on interplay processes life. Default Network cooperates Fronto-Parietal maintain performance cost. Midlife marks shift, prompting prioritizes performance.

Language: Английский

Modeling the neurocognitive dynamics of language across the lifespan DOI Creative Commons
Clément Guichet, Sonja Banjac, Sophie Achard

et al.

Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(5)

Published: March 29, 2024

Abstract Healthy aging is associated with a heterogeneous decline across cognitive functions, typically observed between language comprehension and production (LP). Examining resting‐state fMRI neuropsychological data from 628 healthy adults (age 18–88) the CamCAN cohort, we performed state‐of‐the‐art graph theoretical analysis to uncover neural mechanisms underlying this variability. At level, our findings suggest that LP not an isolated function but modulated throughout lifespan by extent of inter‐cognitive synergy semantic domain‐general processes. cerebral show default mode network (DMN) suppression coupled fronto‐parietal (FPN) integration way for brain compensate effects dedifferentiation at minimal cost, efficiently mitigating age‐related in LP. Relatedly, reduced DMN midlife could compromise ability manage cost FPN integration. This may prompt older adopt more cost‐efficient compensatory strategy maintains global homeostasis expense performances. Taken together, propose represents critical neurocognitive juncture signifies onset decline, as gradually lose control over representations. We summarize novel synergistic, economical, nonlinear, emergent, model, integrating connectomic dimensions within complex system perspective.

Language: Английский

Citations

4
Sex-specific differences in brain activity dynamics of youth with a family history of substance use disorder DOI Creative Commons
Louisa Schilling, S. Parker Singleton, Ceren Tozlu

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 4, 2024

An individual's risk of substance use disorder (SUD) is shaped by a complex interplay potent biosocial factors. Current neurodevelopmental models posit vulnerability to SUD in youth due an overreactive reward system and reduced inhibitory control. Having family history particularly strong factor, yet few studies have explored its impact on brain function structure prior exposure. Herein, we utilized network control theory approach quantify sex-specific differences activity dynamics with without SUD, drawn from large cohort substance-naïve the Adolescent Brain Cognitive Development Study. We summarize calculating transition energy, which probes ease whole brain, region or drives towards specific spatial pattern activation (i.e., state). Our findings reveal that associated alterations brain's wherein: i) independent sex, certain regions' energies are higher those ii) there exist groups at multiple levels energy (global, network, regional). Family history-by-sex effects energetic demand increased females decreased males compared their same-sex counterparts no history. Specifically, localize these demands default mode lower attention networks SUD. These results suggest may increase saliency decrease efficiency top-down females. This work could be used inform personalized intervention strategies target differing cognitive mechanisms predispose individuals development

Language: Английский

Citations

0
Modeling the Neurocognitive Dynamics of Language across the Lifespan DOI Creative Commons
Clément Guichet, Sonja Banjac, Sophie Achard

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: July 4, 2023

Abstract Healthy aging is associated with a heterogeneous decline across cognitive functions, typically observed between language comprehension and production (LP). Examining resting-state fMRI neuropsychological data from 628 healthy adults (age 18-88) the CamCAN cohort, we performed state-of-the-art graph theoretical analysis to uncover neural mechanisms underlying this variability. At level, our findings suggest that LP not an isolated function but modulated throughout lifespan by extent of inter-cognitive synergy semantic domain-general processes. cerebral show DMN (Default Mode Network) suppression coupled FPN (Fronto-Parietal integration way for brain compensate effects dedifferentiation at minimal cost, efficiently mitigating age-related in LP. Relatedly, reduced midlife could compromise ability manage cost integration. This may prompt older adopt more cost-efficient compensatory strategy maintains global homeostasis expense performances. Taken together, propose represents critical neurocognitive juncture signifies onset decline, as gradually lose control over representations. We summarize novel SENECA model (Synergistic, Economical, Nonlinear, Emergent, Cognitive Aging), integrating connectomic dimensions within complex system perspective. Highlights Lexical ( ) relies on interplay processes life. Default Network cooperates Fronto-Parietal maintain performance cost. Midlife marks shift, prompting prioritizes performance.

Language: Английский

Citations

1