An Adipo-Pulmonary Axis Mediated by FABP4 Hormone Defines a Therapeutic Target Against Obesity-Induced Airway Disease DOI
M. Furkan Burak, Gürol Tuncman,

Ayse Nur Ayci

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 18, 2024

Obesity-related airway disease is a clinical condition without clear description and effective treatment. Here, we define this pathology its unique properties, which differ from classic asthma phenotypes, identify novel adipo-pulmonary axis mediated by FABP4 hormone as critical mediator of obesity-induced disease. Through detailed analysis murine models human samples, elucidate the dysregulated lipid metabolism immunometabolic responses within obese lungs, particularly highlighting stress response activation downregulation surfactant-related genes, notably SftpC. We demonstrate that deficiency mitigates these alterations, demonstrating key role in pathogenesis. Importantly, adipose tissue source bronchoalveolar space describe strong regulation context obesity, among women. Finally, our exploration antibody-mediated targeting circulating unveils therapeutic avenue, addressing pressing unmet need managing obesity-related These findings not only presence endocrine link but also present target for refer to fatty lung associated with obesity.

Language: Английский

An Adipo-Pulmonary Axis Mediated by FABP4 Hormone Defines a Therapeutic Target Against Obesity-Induced Airway Disease DOI
M. Furkan Burak, Gürol Tuncman,

Ayse Nur Ayci

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 18, 2024

Obesity-related airway disease is a clinical condition without clear description and effective treatment. Here, we define this pathology its unique properties, which differ from classic asthma phenotypes, identify novel adipo-pulmonary axis mediated by FABP4 hormone as critical mediator of obesity-induced disease. Through detailed analysis murine models human samples, elucidate the dysregulated lipid metabolism immunometabolic responses within obese lungs, particularly highlighting stress response activation downregulation surfactant-related genes, notably SftpC. We demonstrate that deficiency mitigates these alterations, demonstrating key role in pathogenesis. Importantly, adipose tissue source bronchoalveolar space describe strong regulation context obesity, among women. Finally, our exploration antibody-mediated targeting circulating unveils therapeutic avenue, addressing pressing unmet need managing obesity-related These findings not only presence endocrine link but also present target for refer to fatty lung associated with obesity.

Language: Английский

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