Increased functional connectivity between brain regions involved in social cognition, emotion and affective-value in psychedelic states induced by N,N-Dimethyltryptamine (DMT) DOI Creative Commons
Carla Soares, Gisela Lima, Marta Lapo Pais

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 30, 2024

The modulation of social cognition is suggested as a possible mechanism contributing to the potential clinical efficacy psychedelics in disorders involving socio-emotional and reward processing deficits. Resting-state functional Magnetic Resonance Imaging (rs-fMRI) can be used detect changes brain connectivity during psychedelic-induced states. Thus, this pharmacoimaging study investigates effects N,N-Dimethyltryptamine (DMT) on areas relevant cognition, using within-subject design eleven healthy experienced users. included both an active control condition, conducted at different time points. condition involved DMT inhalation, while did not. Seed-based was measured for two core regions theory mind emotional processing, respectively, posterior supramarginal gyrus amygdala. increased with precuneus, cingulate gyrus, amygdala, orbitofrontal cortex. Additionally, emerged between amygdala These results demonstrate that modulates affective-value circuits, advancing our understanding neural mechanisms underlying psychedelic experience its therapeutic action.

Language: Английский

Increased functional connectivity between brain regions involved in social cognition, emotion and affective-value in psychedelic states induced by N,N-Dimethyltryptamine (DMT) DOI Creative Commons
Carla Soares, Gisela Lima, Marta Lapo Pais

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 30, 2024

The modulation of social cognition is suggested as a possible mechanism contributing to the potential clinical efficacy psychedelics in disorders involving socio-emotional and reward processing deficits. Resting-state functional Magnetic Resonance Imaging (rs-fMRI) can be used detect changes brain connectivity during psychedelic-induced states. Thus, this pharmacoimaging study investigates effects N,N-Dimethyltryptamine (DMT) on areas relevant cognition, using within-subject design eleven healthy experienced users. included both an active control condition, conducted at different time points. condition involved DMT inhalation, while did not. Seed-based was measured for two core regions theory mind emotional processing, respectively, posterior supramarginal gyrus amygdala. increased with precuneus, cingulate gyrus, amygdala, orbitofrontal cortex. Additionally, emerged between amygdala These results demonstrate that modulates affective-value circuits, advancing our understanding neural mechanisms underlying psychedelic experience its therapeutic action.

Language: Английский

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