The effects of alcohol use severity and polygenic risk on gray matter volumes in young adults DOI Creative Commons
Yu Chen,

Huey-Ting Li,

Xingguang Luo

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Abstract Genetic factors contribute to alcohol misuse. Chronic consumption is associated with decreases in gray matter volumes (GMVs) of the brain. However, it remains unclear whether or how genetic risks may alter GMVs independent effects exposure. Here, we employed Human Connectome Project data neurotypical adults (n = 995; age 22-35; 618 women) and, voxel-based morphometry analysis, computed 166 regions automated anatomical atlas 3. Alcohol use behaviors were assessed Semi-Structured Assessment for Genetics Alcoholism. severity was quantified by first principal component (PC1) identified analysis 15 drinking measures. Polygenic risk scores (PRS) dependence all subjects using Psychiatric Genomics Consortium study as base sample. With age, sex, race, and total intracranial volume covariates, evaluated relationships regional PC1 PRS together a linear regression. negatively correlated right insula Heschl’s gyrus, positively left posterior orbitofrontal cortex, bilateral intralaminar nuclei thalamus lingual gyri. These findings suggest distinct volumetric neural markers Notably, contrast reduction, dependent involve larger reward, emotion, saliency circuits.

Language: Английский

Higher amplitudes of visual networks are associated with trait- but not state-depression DOI Creative Commons
Wei Zhang, Rosie Dutt, Daphne Lew

et al.

Psychological Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: Jan. 6, 2025

Despite depression being a leading cause of global disability, neuroimaging studies have struggled to identify replicable neural correlates or explain limited variance. This challenge may, in part, stem from the intertwined state (current symptoms; variable) and trait (general propensity; stable) experiences depression.Here, we sought disentangle by leveraging longitudinal cohort stratifying individuals into four groups: those remission ('trait group'), with large severity changes symptomatology ('state their respective matched control groups (total analytic

Language: Английский

Citations

0
The effects of alcohol use severity and polygenic risk on gray matter volumes in young adults DOI Creative Commons
Yu Chen,

Huey-Ting Li,

Xingguang Luo

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Abstract Genetic factors contribute to alcohol misuse. Chronic consumption is associated with decreases in gray matter volumes (GMVs) of the brain. However, it remains unclear whether or how genetic risks may alter GMVs independent effects exposure. Here, we employed Human Connectome Project data neurotypical adults (n = 995; age 22-35; 618 women) and, voxel-based morphometry analysis, computed 166 regions automated anatomical atlas 3. Alcohol use behaviors were assessed Semi-Structured Assessment for Genetics Alcoholism. severity was quantified by first principal component (PC1) identified analysis 15 drinking measures. Polygenic risk scores (PRS) dependence all subjects using Psychiatric Genomics Consortium study as base sample. With age, sex, race, and total intracranial volume covariates, evaluated relationships regional PC1 PRS together a linear regression. negatively correlated right insula Heschl’s gyrus, positively left posterior orbitofrontal cortex, bilateral intralaminar nuclei thalamus lingual gyri. These findings suggest distinct volumetric neural markers Notably, contrast reduction, dependent involve larger reward, emotion, saliency circuits.

Language: Английский

Citations

0