Synthesis and Biological Evaluation of a Series of New Hybrid Amide Derivatives of Triazole and Thiazolidine-2,4-dione

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(6), P. 723 - 723

Published: June 3, 2024

A series of hybrid compounds with triazole and thiazolidine nuclei connected by a linker has been synthesized extensively studied. Various synthetic methods for the target have tested. microbiological assessment obtained was carried out on strains pathogenic fungi C. albicans, non-albicans, multidrug-resistant auris, Rhizopus arrhizus, Aspergillus spp. some dermatophytes other yeasts. The lowest MIC values lie between 0.003 µg/mL 0.5 therefore are not inferior or several times better than commercial azole drugs. length acylpiperazine limited effect antifungal activity. Some bioisosteric analogues were tested in analysis, but turned to be weaker leader highest activity demonstrated compound para-chlorobenzylidene substituent fragment. Molecular modelling used predict binding modes molecules rationalize experimentally observed SAR. is twice more effective inhibiting formation germ tubes Candida albicans yeast cells compared voriconazole. An increased level Pdr5, an azoles drug efflux pump observed, increase lower that caused azoles. results can useful further development powerful safe agents.

Language: Английский

High-Affinity Plasma Membrane Ca2+ Channel Cch1 Modulates Adaptation to Sodium Dodecyl Sulfate-Triggered Rise in Cytosolic Ca2+ Concentration in Ogataea parapolymorpha

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11450 - 11450

Published: Oct. 25, 2024

The cytosolic calcium concentration ([Ca

Language: Английский