A dual-pathway architecture enables chronic stress to promote habit formation DOI Creative Commons
Jacqueline Giovanniello,

Natalie Paredes,

Anna Wiener

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 3, 2023

ABSTRACT Chronic stress can change how we learn and, thus, make decisions. Here investigated the neuronal circuit mechanisms that enable this. Using a multifaceted systems neuroscience approach in male and female mice, reveal dual pathway, amygdala-striatal architecture by which recent history of chronic disrupts action-outcome learning underlying adaptive agency promotes formation inflexible habits. We found basolateral amygdala projection to dorsomedial striatum is activated rewarding events support needed for flexible, goal-directed decision making. attenuates this disrupt therefore, agency. Conversely, central mediates habit formation. Following pathway progressively recruited promote premature Thus, exerts opposing effects on two pathways habit. These data provide insights into shapes making, help understand lead disrupted making pathological habits characterize substance use disorders mental health conditions.

Language: Английский

A dual-pathway architecture for stress to disrupt agency and promote habit DOI
Jacqueline Giovanniello,

Natalie Paredes,

Anna Wiener

et al.

Nature, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Language: Английский

Citations

1
A dual-pathway architecture enables chronic stress to promote habit formation DOI Creative Commons
Jacqueline Giovanniello,

Natalie Paredes,

Anna Wiener

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 3, 2023

ABSTRACT Chronic stress can change how we learn and, thus, make decisions. Here investigated the neuronal circuit mechanisms that enable this. Using a multifaceted systems neuroscience approach in male and female mice, reveal dual pathway, amygdala-striatal architecture by which recent history of chronic disrupts action-outcome learning underlying adaptive agency promotes formation inflexible habits. We found basolateral amygdala projection to dorsomedial striatum is activated rewarding events support needed for flexible, goal-directed decision making. attenuates this disrupt therefore, agency. Conversely, central mediates habit formation. Following pathway progressively recruited promote premature Thus, exerts opposing effects on two pathways habit. These data provide insights into shapes making, help understand lead disrupted making pathological habits characterize substance use disorders mental health conditions.

Language: Английский

Citations

5