Understanding the Impact of Social Stress on Serum Metabolome and Saliva Biomarkers in Growing–Finishing Pigs DOI Creative Commons
Marc Bagaria, Núria Tous, D. Torrallardona

et al.

Animals, Journal Year: 2025, Volume and Issue: 15(9), P. 1228 - 1228

Published: April 27, 2025

High levels of social stress are known to negatively impact pig welfare. The aim this study was evaluate the in growing–finishing pigs by measuring serum metabolome changes and saliva biomarkers. Seventy-two undocked (thirty-six males thirty-six females) were housed single-sex pens four, with second dominant each pen selected as focal pig. A challenge conducted mixing three new its home on two consecutive days trial 62–64. Saliva blood samples collected, pigs’ behaviour body lesions evaluated pre- post-challenge. total 630 metabolites analysed, 292 which could be statistically compared using Biocrates WebIDQ v5 software. Salivary haptoglobin concentrations number significantly increased after (p < 0.001), whereas average daily weight gain decreased 0.05). showed decreases essential amino acids (Thr, Met, Phe), non-essential (Glu, Asn, Asp, Pro, Tyr), betaine, ornithine, indoxyl sulphate, taurine, some di- triacylglycerols (q 0.05), increases oleic, eicosanoic, eicosadienoic, dihomo-gamma-linolenic acids; EPA; DHA post-challenge Overall, results suggest potential metabolomics a tool providing more holistic view stress.

Language: Английский

Gut-Brain Axis: Role of Microbiome, Metabolomics, Hormones, and Stress in Mental Health Disorders DOI Creative Commons

Ankita Verma,

Sabra S. Inslicht,

Aditi Bhargava

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(17), P. 1436 - 1436

Published: Aug. 27, 2024

The influence of gut microbiome, metabolites, omics, hormones, and stress on general mental health is increasingly being recognized. Ancient cultures recognized the importance diet overall an individual. Western science modern scientific methods are beginning to unravel foundations mechanisms behind some ancient beliefs customs. organ itself, now thought almost all other organs, ranging from brain reproductive systems. Gut biological sex also a myriad conditions that range disorders, obesity, gastrointestinal cardiovascular diseases health. Here, we review history current understanding gut-brain axis bidirectional talk in various disorders with special emphasis anxiety depressive whose prevalence has increased by over 50% past three decades COVID-19 pandemic biggest risk factor last few years. vagal nerve important contributor this talk, but pathways contribute, most remain understudied. Probiotics containing

Language: Английский

Citations

13
Understanding the Impact of Social Stress on Serum Metabolome and Saliva Biomarkers in Growing–Finishing Pigs DOI Creative Commons
Marc Bagaria, Núria Tous, D. Torrallardona

et al.

Animals, Journal Year: 2025, Volume and Issue: 15(9), P. 1228 - 1228

Published: April 27, 2025

High levels of social stress are known to negatively impact pig welfare. The aim this study was evaluate the in growing–finishing pigs by measuring serum metabolome changes and saliva biomarkers. Seventy-two undocked (thirty-six males thirty-six females) were housed single-sex pens four, with second dominant each pen selected as focal pig. A challenge conducted mixing three new its home on two consecutive days trial 62–64. Saliva blood samples collected, pigs’ behaviour body lesions evaluated pre- post-challenge. total 630 metabolites analysed, 292 which could be statistically compared using Biocrates WebIDQ v5 software. Salivary haptoglobin concentrations number significantly increased after (p < 0.001), whereas average daily weight gain decreased 0.05). showed decreases essential amino acids (Thr, Met, Phe), non-essential (Glu, Asn, Asp, Pro, Tyr), betaine, ornithine, indoxyl sulphate, taurine, some di- triacylglycerols (q 0.05), increases oleic, eicosanoic, eicosadienoic, dihomo-gamma-linolenic acids; EPA; DHA post-challenge Overall, results suggest potential metabolomics a tool providing more holistic view stress.

Language: Английский

Citations

0