Reactive Oxygen Species as a Common Pathological Link Between Alcohol Use Disorder and Alzheimer’s Disease with Therapeutic Implications DOI Open Access
Ho-Young Song, Jiyong Lee, Yeeun Lee

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3272 - 3272

Published: April 1, 2025

Chronic alcohol consumption leads to excessive production of reactive oxygen species (ROS), driving oxidative stress that contributes both use disorder (AUD) and Alzheimer's disease (AD). This review explores how ROS-mediated mitochondrial dysfunction neuroinflammation serve as shared pathological mechanisms linking these conditions. We highlight the role alcohol-induced damage in exacerbating neurodegeneration compare ROS-related pathways AUD AD. Finally, we discuss emerging therapeutic strategies, including antioxidants inflammasome inhibitors, target mitigate neurodegeneration. Understanding overlapping may provide new insights for preventing treating ROS-driven neurodegenerative disorders.

Language: Английский

Reactive Oxygen Species as a Common Pathological Link Between Alcohol Use Disorder and Alzheimer’s Disease with Therapeutic Implications DOI Open Access
Ho-Young Song, Jiyong Lee, Yeeun Lee

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3272 - 3272

Published: April 1, 2025

Chronic alcohol consumption leads to excessive production of reactive oxygen species (ROS), driving oxidative stress that contributes both use disorder (AUD) and Alzheimer's disease (AD). This review explores how ROS-mediated mitochondrial dysfunction neuroinflammation serve as shared pathological mechanisms linking these conditions. We highlight the role alcohol-induced damage in exacerbating neurodegeneration compare ROS-related pathways AUD AD. Finally, we discuss emerging therapeutic strategies, including antioxidants inflammasome inhibitors, target mitigate neurodegeneration. Understanding overlapping may provide new insights for preventing treating ROS-driven neurodegenerative disorders.

Language: Английский

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