Pervasive loss of regulated necrotic cell death genes in elephants, hyraxes, and sea cows (Paenungualta) DOI Creative Commons

Meaghan Birkemeier,

Arianna Swindle,

Jacob D. Bowman

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 5, 2024

Abstract Gene loss can promote phenotypic differences between species, for example, if a gene constrains variation in trait, its allows the evolution of greater range or even new phenotypes. Here, we explore contribution to large bodies and augmented cancer resistance elephants. We used genomes from 17 Afrotherian Xenarthran species identify lost genes, i.e., genes that have pseudogenized been completely lost, Dollo parsimony reconstruct evolutionary history across species. unexpectedly discovered burst losses stem lineage found with functions regulated necrotic cell death modes was pervasive elephants, hyraxes, sea cows ( Paenungulata ). Among are MLKL RIPK3 , which mediate necroptosis, sensors activate inflammasomes induce pyroptosis, including AIM2 MEFV NLRC4 NLRP1 NLRP6 . These data suggest mechanisms regulate necrosis pyroptosis either extremely derived potentially these lineages, may contribute repeated Paenungulates as well susceptibility pathogen infection.

Language: Английский

Peto’s paradox revisited (revisited, revisited, revisited, and revisited yet again) DOI Creative Commons
Vincent J. Lynch

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(14)

Published: March 31, 2025

Emotions coordinate our behavior and physiological states during survival-salient events pleasurable interactions. Even though we are often consciously aware of current emotional state, such as anger or happiness, the mechanisms giving ...Emotions felt in body, somatosensory feedback has been proposed to trigger conscious experiences. Here reveal maps bodily sensations associated with different emotions using a unique topographical self-report method. In ...

Language: Английский

Citations

0
Pervasive loss of regulated necrotic cell death genes in elephants, hyraxes, and sea cows (Paenungualta) DOI Creative Commons

Meaghan Birkemeier,

Arianna Swindle,

Jacob D. Bowman

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 5, 2024

Abstract Gene loss can promote phenotypic differences between species, for example, if a gene constrains variation in trait, its allows the evolution of greater range or even new phenotypes. Here, we explore contribution to large bodies and augmented cancer resistance elephants. We used genomes from 17 Afrotherian Xenarthran species identify lost genes, i.e., genes that have pseudogenized been completely lost, Dollo parsimony reconstruct evolutionary history across species. unexpectedly discovered burst losses stem lineage found with functions regulated necrotic cell death modes was pervasive elephants, hyraxes, sea cows ( Paenungulata ). Among are MLKL RIPK3 , which mediate necroptosis, sensors activate inflammasomes induce pyroptosis, including AIM2 MEFV NLRC4 NLRP1 NLRP6 . These data suggest mechanisms regulate necrosis pyroptosis either extremely derived potentially these lineages, may contribute repeated Paenungulates as well susceptibility pathogen infection.

Language: Английский

Citations

0