Partial renal deletion of Klotho is not sufficient to impact renal electrolyte handling in distal convoluted tubule specific knock‐out mice
Physiological Reports,
Journal Year:
2025,
Volume and Issue:
13(7)
Published: April 1, 2025
Abstract
Klotho
controls
renal
electrolyte
handling
by
modulating
tubular
reabsorption
of
calcium
and
phosphate
through
the
epithelial
channel
TRPV5
sodium
co‐transporter
NPT2A.
The
Ksp‐KL
−/−
mice
have
a
targeted
deletion
in
distal
part
nephron.
Considering
that
convoluted
tubule
is
most
important
site
for
Ca
2+
regulation
kidney,
were
challenged
with
‐deficient
diet
determining
pinpointing
levels
needed
controlling
handling.
displayed
normal
weight
showed
unaltered
serum
24‐h
urine.
Expression
calciotropic
(
Trpv5
,
Trpv6
)
phosphotropic
Slc34a1
Slc34a2
genes
kidneys,
duodenum,
ileum,
colon
not
affected
deletion.
In
conclusion,
our
study
reports
18%–93%
residual
kidney
exhibit
homeostasis
when
placed
on
low
‐content
diet.
Language: Английский
Lessons from Klotho mouse models to understand mineral homeostasis
Acta Physiologica,
Journal Year:
2024,
Volume and Issue:
240(10)
Published: Aug. 23, 2024
Abstract
Aim
Klotho,
a
key
component
of
the
endocrine
fibroblast
growth
factor
receptor—fibroblast
axis,
is
multi‐functional
protein
that
impacts
renal
electrolyte
handling.
The
physiological
significance
Klotho
will
be
highlighted
in
regulation
calcium,
phosphate,
and
potassium
metabolism.
Methods
In
this
review,
we
compare
several
murine
models
with
different
targeted
deletions
insights
into
molecular
function
these
offer.
Results
vivo,
deficiency
associated
severely
impaired
mineral
metabolism,
consequences
on
growth,
longevity
disease
development.
Additionally,
explore
perspectives
pathology
vascular
events,
as
well
potential
treatment
options.
Conclusion
This
comprehensive
review
emphasizes
use
to
shed
light
deciphering
vivo
mechanisms
handling,
novel
therapeutic
interventions.
Language: Английский