A New Role for RNA G-quadruplexes in Aging and Alzheimer’s Disease

eLife, Journal Year: 2025, Volume and Issue: 14

Published: Jan. 14, 2025

As the world population ages, new molecular targets in aging and Alzheimer's disease (AD) are needed to combat expected influx of AD cases. Until now, role RNA structure neurodegeneration has largely remained unexplored. In this study, we examined human hippocampal postmortem tissue for formation G-quadruplexes (rG4s) AD. We found that rG4 immunostaining strongly increased hippocampus with both age severity. further neurons accumulation phospho-tau contained rG4s, can drive tau aggregation, staining density depended on APOE genotype examined. Combined previous studies showing dependence stress extreme power rG4s at oligomerizing proteins, propose a model which chronic is linked proteostasis collapse. These morphological findings suggest investigation critical avenue future treatments diagnoses.

Language: Английский

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A New Role for RNA G-quadruplexes in Aging and Alzheimer’s Disease

Published: Jan. 14, 2025

As the world population ages, new molecular targets in aging and Alzheimer’s Disease (AD) are needed to combat expected influx of AD cases. Until now, role RNA structure neurodegeneration has largely remained unexplored. METHODS: In this study, we examined human hippocampal postmortem tissue for formation G-quadruplexes (rG4s) AD.We found that rG4 immunostaining strongly increased hippocampus with both age severity. We further neurons accumulation phospho-tau contained rG4s, can drive tau aggregation, staining density depended on APOE genotype examined.Combined previous studies showing dependence stress extreme power rG4s at oligomerizing proteins, propose a model which chronic drives proteostasis collapse. These morphological findings suggest investigation is critical avenue future treatments diagnoses.

Language: Английский

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Chronic RNA G-quadruplex Accumulation in Aging and Alzheimer’s Disease

Published: Feb. 3, 2025

As the world population ages, new molecular targets in aging and Alzheimer’s Disease (AD) are needed to combat expected influx of AD cases. Until now, role RNA structure neurodegeneration has largely remained unexplored.In this study, we examined human hippocampal postmortem tissue for formation G-quadruplexes (rG4s) AD.We found that rG4 immunostaining strongly increased hippocampus with both age severity. We further neurons accumulation phospho-tau contained rG4s, can drive tau aggregation, staining density depended on APOE genotype examined.Combined previous studies showing dependence stress extreme power rG4s at oligomerizing proteins, propose a model which chronic is linked proteostasis collapse. These morphological findings suggest investigation critical avenue future treatments diagnoses.

Language: Английский

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Chronic RNA G-quadruplex accumulation in aging and Alzheimer’s disease

eLife, Journal Year: 2025, Volume and Issue: 14

Published: Feb. 24, 2025

As the world population ages, new molecular targets in aging and Alzheimer’s disease (AD) are needed to combat expected influx of AD cases. Until now, role RNA structure neurodegeneration has largely remained unexplored. In this study, we examined human hippocampal postmortem tissue for formation G-quadruplexes (rG4s) AD. We found that rG4 immunostaining strongly increased hippocampus with both age severity. further neurons accumulation phospho-tau contained rG4s, can drive tau aggregation, staining density depended on APOE genotype examined. Combined previous studies showing dependence stress extreme power rG4s at oligomerizing proteins, propose a model which chronic is linked proteostasis collapse. These morphological findings suggest investigation critical avenue future treatments diagnoses.

Language: Английский

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A New Role for RNA G-quadruplexes in Aging and Alzheimer’s Disease

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 2, 2023

As the world population ages, new molecular targets in aging and Alzheimer's Disease (AD) are needed to combat expected influx of AD cases. Until now, role RNA structure neurodegeneration has largely remained unexplored.

Language: Английский

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Recent findings on the mechanism underlying neurodegeneration by liquid-liquid phase separation

Folia Pharmacologica Japonica, Journal Year: 2024, Volume and Issue: 159(4), P. 284 - 284

Published: June 30, 2024

Language: Английский

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